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• W1968858550 abstract "No AccessJournal of UrologyInvestigative Urology1 Jul 2009Ice Water Testing Reveals Hypersensitivity in Adult Rats That Experienced Neonatal Bladder Inflammation: Implications for Painful Bladder Syndrome/Interstitial Cystitisis companion ofClinical Phenotyping of Women With Interstitial Cystitis/Painful Bladder Syndrome: A Key to Classification and Potentially Improved Management Alan Randich, Hannah Mebane, and Timothy J. Ness Alan RandichAlan Randich More articles by this author , Hannah MebaneHannah Mebane More articles by this author , and Timothy J. NessTimothy J. Ness More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.02.107AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined whether clinical observations of hypersensitivity to ice water testing, that is infusion of ice-cold saline into the bladder, in patients with painful bladder syndrome/interstitial cystitis have a parallel in a rat model of bladder hypersensitivity produced by neonatal inflammation. Materials and Methods: Rat pups were anesthetized as neonates (postnatal days 14 to 16). In some pups the bladder was inflamed by intravesical zymosan treatment. As adults, the rats were re-anesthetized and tested for abdominal muscle contractions to ice water testing, measured on electromyogram. Various neonatally treated groups of rats underwent bladder re-inflammation/no re-inflammation and/or bladder distention before ice water testing. Other control rats were treated only in adulthood. Results: Rats that underwent bladder inflammation as neonates manifested bladder hypersensitivity in adulthood, as indexed by significantly greater mean electromyogram responses during ice water testing. This bladder hypersensitivity did not require adult re-inflammation to manifest. Hypersensitivity was also observed with or without prior bladder distention, although the magnitude of electromyogram responses during ice water testing significantly correlated with the magnitude of electromyogram responses to bladder distention. Neonatally induced effects were not significantly related to estrous cycle phase. Exposure to menthol did not significantly enhance the overall magnitude of the electromyogram response to ice water testing in neonatally treated rats. Conclusions: Current results parallel those in a recent study showing that most patients with painful bladder syndrome/interstitial cystitis experience pain when undergoing ice water testing after previous urodynamic testing. These findings suggest that this animal model may be useful for understanding the etiology of and treatment for painful bladder syndrome/interstitial cystitis. References 1 : Pain during ice water test distinguishes clinical bladder hypersensitivity from overactivity disorders. BMC Urol2006; 6: 31. Google Scholar 2 : Neonatal urinary bladder inflammation produces adult bladder hypersensitivity. J Pain2006; 7: 468. Google Scholar 3 : Inflammation-induced enhancement of the visceromotor reflex to urinary bladder distention: modulation by endogenous opioids and the effects of early-in-life experience with bladder inflammation. J Pain2007; 8: 914. Google Scholar 4 : Effects of early-in-life bladder inflammation on spontaneous micturition and micturition reflexes during cystometry. Soc Neurosci Abstr2005; . Google Scholar 5 : Altered nociceptive neuronal circuits after neonatal peripheral inflammation. Science2000; 289: 628. Google Scholar 6 : A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterol2000; 119: 1276. Google Scholar 7 : Abdominal muscle activity during voiding in female rats or irritated bladder. Am J Physiol Regul Integr Comp Physiol2005; 290: R1436. Google Scholar 8 : TRP ion channels and temperature sensation. Ann Rev Neurosci2006; 29: 135. Google Scholar 9 : The emerging role of TRP channels in mechanisms of temperature and pain sensation. Curr Neuropharmacol2006; 4: 183. Google Scholar 10 : How cold is it?: TRPM8 and TRPA1 in the molecular logic of cold sensation. Molec Pain2005; 1: 16. Google Scholar 11 : Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations. BMC Urol2006; 6: 6. Google Scholar Departments of Psychology and Anesthesiology (TJN), University of Alabama at Birmingham, Birmingham, Alabama© 2009 by American Urological AssociationFiguresReferencesRelatedDetailsCited byShaffer A, Ness T, Robbins M and Randich A (2018) Early in Life Bladder Inflammation Alters Opioid Peptide Content in the Spinal Cord and Bladder of Adult Female RatsJournal of Urology, VOL. 189, NO. 1, (352-358), Online publication date: 1-Jan-2013.Related articlesJournal of Urology18 May 2009Clinical Phenotyping of Women With Interstitial Cystitis/Painful Bladder Syndrome: A Key to Classification and Potentially Improved Management Volume 182Issue 1July 2009Page: 337-342 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsrats, Sprague-Dawleycystitis, interstitialanimals, newbornhypersensitivityurinary bladderMetricsAuthor Information Alan Randich More articles by this author Hannah Mebane More articles by this author Timothy J. Ness More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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• W1968858550 title "Ice Water Testing Reveals Hypersensitivity in Adult Rats That Experienced Neonatal Bladder Inflammation: Implications for Painful Bladder Syndrome/Interstitial Cystitis" @default.
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