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- W1968885280 abstract "It is believed that gene/environment interaction (GEI) plays a pivotal role in the development of motor skills, which are acquired via practicing or motor training. However, the underlying molecular/neuronal mechanisms are still unclear. Here, we reported that the expression of NR2B, a subunit of NMDA receptors, in cerebellar granule cells specifically enhanced the effect of voluntary motor training on motor learning in the mouse. Moreover, this effect was characterized as motor learning-specific and developmental stage-dependent, because neither emotional/spatial memory was affected nor was the enhanced motor learning observed when the motor training was conducted starting at the age of 3 months old in these transgenic mice. These results indicate that changes in the expression of gene(s) that are involved in regulating synaptic plasticity in cerebellar granule cells may constitute a molecular basis for the cerebellum to be involved in the GEI by facilitating motor skill learning." @default.
- W1968885280 created "2016-06-24" @default.
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- W1968885280 date "2008-02-27" @default.
- W1968885280 modified "2023-09-23" @default.
- W1968885280 title "Expression of NR2B in Cerebellar Granule Cells Specifically Facilitates Effect of Motor Training on Motor Learning" @default.
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- W1968885280 doi "https://doi.org/10.1371/journal.pone.0001684" @default.
- W1968885280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2246013" @default.
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