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• W1968890068 abstract "To evaluate pregnancy outcomes in normotensive second pregnancy following pre-eclampsia in first pregnancy.Population-based retrospective cohort study.State of Missouri in the USA.White European origin or African-American women who delivered their first two non-anomalous singleton pregnancies between 20 and 44 weeks of gestation in Missouri, USA, 1989-2005, without chronic hypertension, renal disease or diabetes mellitus (n = 12 835).Pre-eclampsia or delivery at 34 weeks of gestation or less in first pregnancy was defined as early-onset pre-eclampsia, whereas late-onset pre-eclampsia was defined as pre-eclampsia with delivery after 34 weeks of gestation. Multivariate regression models were fitted to estimate the crude and adjusted odds ratios and 95% confidence intervals.Preterm delivery, large and small-for-gestational-age infant, Apgar scores at 5 minutes, fetal death, caesarean section, placental abruption.Women with early-onset pre-eclampsia in first pregnancy were more likely to be younger, African-American, recipients of Medicaid, unmarried and smokers. Despite a second normotensive pregnancy, women with early-onset pre-eclampsia in their first pregnancy had greater odds of a small-for-gestational-age infant, preterm birth, fetal death, caesarean section and placental abruption in the second pregnancy, relative to women with late-onset pre-eclampsia, after controlling for confounders. Moreover, maternal ethnic origin modified the association between early-onset pre-eclampsia in the first pregnancy and preterm births in the second pregnancy. Having a history of early-onset pre-eclampsia reduces the odds of having a large-for-gestational-age infant in the second pregnancy.A history of early-onset pre-eclampsia is associated with increased odds of adverse pregnancy outcomes despite a normotensive second pregnancy." @default.
• W1968890068 created "2016-06-24" @default.
• W1968890068 creator A5022389836 @default.
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• W1968890068 date "2010-05-25" @default.
• W1968890068 modified "2023-09-26" @default.
• W1968890068 title "Association of early-onset pre-eclampsia in first pregnancy with normotensive second pregnancy outcomes: a population-based study" @default.
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• W1968890068 doi "https://doi.org/10.1111/j.1471-0528.2010.02594.x" @default.
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