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• W1968892287 endingPage "e22474" @default.
• W1968892287 startingPage "e22474" @default.
• W1968892287 abstract "The appearance of cellular cartilage was a defining event in vertebrate evolution because it made possible the physical expansion of the vertebrate new head. Despite its central role in vertebrate evolution, the origin of cellular cartilage has been difficult to understand. This is largely due to a lack of informative evolutionary intermediates linking vertebrate cellular cartilage to the acellular cartilage of invertebrate chordates. The basal jawless vertebrate, lamprey, has long been considered key to understanding the evolution of vertebrate cartilage. However, histological analyses of the lamprey head skeleton suggest it is composed of modern cellular cartilage and a putatively unrelated connective tissue called mucocartilage, with no obvious transitional tissue. Here we take a molecular approach to better understand the evolutionary relationships between lamprey cellular cartilage, gnathostome cellular cartilage, and lamprey mucocartilage. We find that despite overt histological similarity, lamprey and gnathostome cellular cartilage utilize divergent gene regulatory networks (GRNs). While the gnathostome cellular cartilage GRN broadly incorporates Runx, Barx, and Alx transcription factors, lamprey cellular cartilage does not express Runx or Barx, and only deploys Alx genes in certain regions. Furthermore, we find that lamprey mucocartilage, despite its distinctive mesenchymal morphology, deploys every component of the gnathostome cartilage GRN, albeit in different domains. Based on these findings, and previous work, we propose a stepwise model for the evolution of vertebrate cellular cartilage in which the appearance of a generic neural crest-derived skeletal tissue was followed by a phase of skeletal tissue diversification in early agnathans. In the gnathostome lineage, a single type of rigid cellular cartilage became dominant, replacing other skeletal tissues and evolving via gene cooption to become the definitive cellular cartilage of modern jawed vertebrates." @default.
• W1968892287 created "2016-06-24" @default.
• W1968892287 creator A5036285754 @default.
• W1968892287 creator A5059117154 @default.
• W1968892287 creator A5068447066 @default.
• W1968892287 creator A5073037378 @default.
• W1968892287 date "2011-07-22" @default.
• W1968892287 modified "2023-10-10" @default.
• W1968892287 title "A New Mechanistic Scenario for the Origin and Evolution of Vertebrate Cartilage" @default.
• W1968892287 cites W1521657513 @default.
• W1968892287 cites W1537093485 @default.
• W1968892287 cites W1633846818 @default.
• W1968892287 cites W1964528765 @default.
• W1968892287 cites W1964958795 @default.
• W1968892287 cites W1965698106 @default.
• W1968892287 cites W1966312099 @default.
• W1968892287 cites W1967195690 @default.
• W1968892287 cites W1970712767 @default.
• W1968892287 cites W1971568933 @default.
• W1968892287 cites W1974276559 @default.
• W1968892287 cites W1977800834 @default.
• W1968892287 cites W1979852800 @default.
• W1968892287 cites W1981780292 @default.
• W1968892287 cites W1990880194 @default.
• W1968892287 cites W1997035797 @default.
• W1968892287 cites W1997067526 @default.
• W1968892287 cites W1998606837 @default.
• W1968892287 cites W2000883579 @default.
• W1968892287 cites W2001089439 @default.
• W1968892287 cites W2001589227 @default.
• W1968892287 cites W2002801240 @default.
• W1968892287 cites W2005323886 @default.
• W1968892287 cites W2006418826 @default.
• W1968892287 cites W2010446781 @default.
• W1968892287 cites W2012765331 @default.
• W1968892287 cites W2013541072 @default.
• W1968892287 cites W2020448266 @default.
• W1968892287 cites W2022906661 @default.
• W1968892287 cites W2022994060 @default.
• W1968892287 cites W2023070796 @default.
• W1968892287 cites W2025148423 @default.
• W1968892287 cites W2029787649 @default.
• W1968892287 cites W2035934212 @default.
• W1968892287 cites W2036006596 @default.
• W1968892287 cites W2037066960 @default.
• W1968892287 cites W2042873407 @default.
• W1968892287 cites W2045922370 @default.
• W1968892287 cites W2047271695 @default.
• W1968892287 cites W2049294009 @default.
• W1968892287 cites W2050132916 @default.
• W1968892287 cites W2053178092 @default.
• W1968892287 cites W2055557564 @default.
• W1968892287 cites W2057081312 @default.
• W1968892287 cites W2057160874 @default.
• W1968892287 cites W2058534642 @default.
• W1968892287 cites W2066715726 @default.
• W1968892287 cites W2067226341 @default.
• W1968892287 cites W2070771744 @default.
• W1968892287 cites W2082070105 @default.
• W1968892287 cites W2083882414 @default.
• W1968892287 cites W2084070966 @default.
• W1968892287 cites W2086943246 @default.
• W1968892287 cites W2088120545 @default.
• W1968892287 cites W2088583086 @default.
• W1968892287 cites W2088696343 @default.
• W1968892287 cites W2108274213 @default.
• W1968892287 cites W2114541039 @default.
• W1968892287 cites W2123616399 @default.
• W1968892287 cites W2124053456 @default.
• W1968892287 cites W2125721924 @default.
• W1968892287 cites W2126716539 @default.
• W1968892287 cites W2129085644 @default.
• W1968892287 cites W2129790421 @default.
• W1968892287 cites W2136246472 @default.
• W1968892287 cites W2136526854 @default.
• W1968892287 cites W2138305701 @default.
• W1968892287 cites W2139043745 @default.
• W1968892287 cites W2139141488 @default.
• W1968892287 cites W2139250230 @default.
• W1968892287 cites W2144031154 @default.
• W1968892287 cites W2144691140 @default.
• W1968892287 cites W2145802555 @default.
• W1968892287 cites W2146586155 @default.
• W1968892287 cites W2148582994 @default.
• W1968892287 cites W2153391988 @default.
• W1968892287 cites W2154622533 @default.
• W1968892287 cites W2156466651 @default.
• W1968892287 cites W2166604240 @default.
• W1968892287 cites W2185414177 @default.
• W1968892287 cites W2494470297 @default.
• W1968892287 cites W4246844380 @default.
• W1968892287 cites W4255910628 @default.
• W1968892287 doi "https://doi.org/10.1371/journal.pone.0022474" @default.
• W1968892287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3142159" @default.
• W1968892287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21799866" @default.
• W1968892287 hasPublicationYear "2011" @default.
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