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• W1968900809 abstract "Here, we report the synthesis and characterization of an HPMA-based polymer for use as a carrier for the delivery of water soluble drugs. The polymer contains active-sulfhydryl groups for coupling of ligands through a disulfide linkage. The polymer can also be prepared containing pendant amino groups in addition to the active-sulfhydryl moiety. This allows the use of different chemistries to conjugate a variety of ligands to the polymer. We demonstrate that a sulfhydryl-terminated antisense oligonucleotide can be efficiently and rapidly conjugated to the polymer. The polymer-oligonucleotide conjugate is efficiently taken up by cultured cells." @default.
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• W1968900809 date "1998-10-24" @default.
• W1968900809 modified "2023-09-23" @default.
• W1968900809 title "Delivery of Antisense Oligonucleotides Using HPMA Polymer: Synthesis of A Thiol Polymer and Its Conjugation to Water-Soluble Molecules" @default.
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• W1968900809 doi "https://doi.org/10.1021/bc980034k" @default.
• W1968900809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9815169" @default.
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