FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968900944> ?p ?o ?g. }

• W1968900944 endingPage "560" @default.
• W1968900944 startingPage "551" @default.
• W1968900944 abstract "In the current studies, we evaluated the effects of 4-tert-octylphenol (OP), endosulfan, bisphenol A (BPA), and 17β-estradiol on basal or hCG-stimulated testosterone formation by cultured Leydig cells from young adult male rats. Exposure of Leydig cells to increasing concentrations of OP (1 to 2000 nM), 17β-estradiol (1 to 1000 nM), endosulfan (1 to 1000 nM) or BPA (1 to 1000 nM), alone or with 10 mIU/mL hCG for 4 or 24 h, did not lower ambient testosterone levels, although cells exposed to higher OP concentrations + hCG for 24 h often had modest declines in testosterone (10 to 20%). Of interest, exposure to the highest concentration OP (2000 nM) alone for 4 or 24 h increased testosterone levels (∼ 2-fold in 4-h exposed cells). Whether prior exposure to OP + hCG for 24 h affects the subsequent conversion of steroid substrates to testosterone over 4 h was evaluated. Progressive declines in 1 μM 22(R) hydroxycholesterol, 1 μM pregnenolone, or 1 μM progesterone conversion to testosterone was observed beginning at 100 to 500 nM OP exposure (maximal declines of 40 to 12% of controls were observed); however, the conversion of 1 μM androstenedione to testosterone was not affected by OP. These results suggested that 24-h exposure to OP + hCG has no effect on 17β-hydroxysteroid dehydrogenase, which converts androstenedione to testosterone, but that it inhibits the 17α-hydroxylase/C17–20 lyase step, which converts progesterone to androstenedione. In addition, potentially, OP could inhibit cholesterol side/chain cleavage activity, which converts cholesterol to pregnenolone, and/or 3β-hydroxysteroid dehydrogenase, which converts pregnenolone to progesterone. Of interest, exposure to increasing concentrations of 17β-estradiol (1 to 1000 nM), endosulfan (1 to 1000 nM), or BPA (1 to 1000 nM) + hCG for 24 h had no effect on subsequent conversion of 22(R)hydroxycholesterol to testosterone. Furthermore, the inhibiting effects of OP + hCG exposure on subsequent conversion of progesterone to testosterone was unaffected by concomitant exposure to the pure estrogen antagonist, ICI 182,780, or the antioxidants, ascorbate or dimethyl sulfoxide, suggesting that the actions of OP are not mediated through binding to estrogen receptor α or β or by free radical induced damage to steroidogenic enzymes, respectively. These results demonstrate that direct exposure of adult Leydig cells to OP may have subtle effects on their ability to produce testosterone, which may not be detected by measuring ambient androgen levels. In addition, the effects of OP on Leydig cell testosterone formation appear to be different from those of the native estrogen, 17β-estradiol, and from other reported weak xenoestrogens such as endosulfan and BPA." @default.
• W1968900944 created "2016-06-24" @default.
• W1968900944 creator A5004957488 @default.
• W1968900944 creator A5019796793 @default.
• W1968900944 creator A5082201321 @default.
• W1968900944 date "2001-09-01" @default.
• W1968900944 modified "2023-09-27" @default.
• W1968900944 title "Differential effects of octylphenol, 17β-estradiol, endosulfan, or bisphenol A on the steroidogenic competence of cultured adult rat Leydig cells" @default.
• W1968900944 cites W135898729 @default.
• W1968900944 cites W1923943691 @default.
• W1968900944 cites W1948397077 @default.
• W1968900944 cites W1967330120 @default.
• W1968900944 cites W1969492577 @default.
• W1968900944 cites W1978166178 @default.
• W1968900944 cites W1984485242 @default.
• W1968900944 cites W1986310133 @default.
• W1968900944 cites W1991473296 @default.
• W1968900944 cites W1991677957 @default.
• W1968900944 cites W2002194987 @default.
• W1968900944 cites W2007957335 @default.
• W1968900944 cites W2022373675 @default.
• W1968900944 cites W2023704290 @default.
• W1968900944 cites W2026252851 @default.
• W1968900944 cites W2030005169 @default.
• W1968900944 cites W2032743237 @default.
• W1968900944 cites W2039908717 @default.
• W1968900944 cites W2050338170 @default.
• W1968900944 cites W2052013976 @default.
• W1968900944 cites W2053497689 @default.
• W1968900944 cites W2061236466 @default.
• W1968900944 cites W2063760517 @default.
• W1968900944 cites W2065713184 @default.
• W1968900944 cites W2069290661 @default.
• W1968900944 cites W2073264207 @default.
• W1968900944 cites W2074151102 @default.
• W1968900944 cites W2080266891 @default.
• W1968900944 cites W2082506955 @default.
• W1968900944 cites W2083361397 @default.
• W1968900944 cites W2084709535 @default.
• W1968900944 cites W2085102246 @default.
• W1968900944 cites W2087725525 @default.
• W1968900944 cites W2089618682 @default.
• W1968900944 cites W2094052237 @default.
• W1968900944 cites W2094401352 @default.
• W1968900944 cites W2104726413 @default.
• W1968900944 cites W2106162177 @default.
• W1968900944 cites W2106519485 @default.
• W1968900944 cites W2131727903 @default.
• W1968900944 cites W2152119602 @default.
• W1968900944 cites W2152805080 @default.
• W1968900944 cites W2166537089 @default.
• W1968900944 cites W2327758174 @default.
• W1968900944 cites W4241957557 @default.
• W1968900944 cites W4250053222 @default.
• W1968900944 cites W4254093939 @default.
• W1968900944 doi "https://doi.org/10.1016/s0890-6238(01)00158-7" @default.
• W1968900944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11780963" @default.
• W1968900944 hasPublicationYear "2001" @default.
• W1968900944 type Work @default.
• W1968900944 sameAs 1968900944 @default.
• W1968900944 citedByCount "48" @default.
• W1968900944 countsByYear W19689009442012 @default.
• W1968900944 countsByYear W19689009442013 @default.
• W1968900944 countsByYear W19689009442014 @default.
• W1968900944 countsByYear W19689009442015 @default.
• W1968900944 countsByYear W19689009442016 @default.
• W1968900944 countsByYear W19689009442017 @default.
• W1968900944 countsByYear W19689009442018 @default.
• W1968900944 countsByYear W19689009442019 @default.
• W1968900944 countsByYear W19689009442020 @default.
• W1968900944 countsByYear W19689009442022 @default.
• W1968900944 countsByYear W19689009442023 @default.
• W1968900944 crossrefType "journal-article" @default.
• W1968900944 hasAuthorship W1968900944A5004957488 @default.
• W1968900944 hasAuthorship W1968900944A5019796793 @default.
• W1968900944 hasAuthorship W1968900944A5082201321 @default.
• W1968900944 hasConcept C126322002 @default.
• W1968900944 hasConcept C134018914 @default.
• W1968900944 hasConcept C185592680 @default.
• W1968900944 hasConcept C2776683971 @default.
• W1968900944 hasConcept C2777164284 @default.
• W1968900944 hasConcept C2777736315 @default.
• W1968900944 hasConcept C2777911890 @default.
• W1968900944 hasConcept C2778575703 @default.
• W1968900944 hasConcept C2778656385 @default.
• W1968900944 hasConcept C2779279991 @default.
• W1968900944 hasConcept C2780193516 @default.
• W1968900944 hasConcept C2780902042 @default.
• W1968900944 hasConcept C71315377 @default.
• W1968900944 hasConcept C71924100 @default.
• W1968900944 hasConcept C86803240 @default.
• W1968900944 hasConceptScore W1968900944C126322002 @default.
• W1968900944 hasConceptScore W1968900944C134018914 @default.
• W1968900944 hasConceptScore W1968900944C185592680 @default.
• W1968900944 hasConceptScore W1968900944C2776683971 @default.
• W1968900944 hasConceptScore W1968900944C2777164284 @default.
• W1968900944 hasConceptScore W1968900944C2777736315 @default.
• W1968900944 hasConceptScore W1968900944C2777911890 @default.

• next