FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968925407> ?p ?o ?g. }

• W1968925407 endingPage "646" @default.
• W1968925407 startingPage "639" @default.
• W1968925407 abstract "We investigated the effect of BQ-123, a selective endothelin-A (ETA) receptor antagonist in ischemia-reperfusion (IR) induced myocardial infarction (MI) with and without endothelin-1 (ET-1) challenge. MI was produced in rats by occlusion of left anterior descending coronary artery for 40 min and reperfusion for 120 min. ET-1 was administered immediately prior to coronary occlusion whereas vehicle or BQ-123 was administered 20 min after the occlusion. IR control group exhibited marked hemodynamic changes along with significant impairment of left ventricular functions. In addition, oxidative stress was increased, as evidenced by marked reduction in the activities of antioxidants and cardiac injury markers in myocardium. Furthermore, light microscopic and ultrastructural changes revealed myocardial necrosis, edema and inflammation. Prior administration of ET-1 acts synergistically with IR injury and further aggravates the impairment of ventricular functions, increased percent infarct area and decreased antioxidant levels. However, treatment with BQ-123 (1 mg/kg, IV) with or without ET-1 caused significant improvement in cardiac functions, percent infarct area, decreased malonaldehyde level, restored myocardial enzymes activities and maintained the redox status of the myocardium as compared to IR control group. Further, histopathological and ultrastructural studies reconfirmed the protective action of BQ-123. The results of present study suggest that ET-1 acting via ETA receptor may exaggerate myocardial damage produced by IR injury and selective blockade of ETA receptor by BQ-123 might offer potential cardioprotective action." @default.
• W1968925407 created "2016-06-24" @default.
• W1968925407 creator A5008387075 @default.
• W1968925407 creator A5058704454 @default.
• W1968925407 creator A5066017080 @default.
• W1968925407 creator A5066440800 @default.
• W1968925407 creator A5084761023 @default.
• W1968925407 date "2010-11-01" @default.
• W1968925407 modified "2023-10-15" @default.
• W1968925407 title "Endothelin receptor antagonist BQ-123 ameliorates myocardial ischemic-reperfusion injury in rats: A hemodynamic, biochemical, histopathological and electron microscopic evidence" @default.
• W1968925407 cites W1971563903 @default.
• W1968925407 cites W1979846966 @default.
• W1968925407 cites W1983310681 @default.
• W1968925407 cites W1989160290 @default.
• W1968925407 cites W1991616211 @default.
• W1968925407 cites W2016837466 @default.
• W1968925407 cites W2017512397 @default.
• W1968925407 cites W2022709209 @default.
• W1968925407 cites W2027415631 @default.
• W1968925407 cites W2031317046 @default.
• W1968925407 cites W2040589610 @default.
• W1968925407 cites W2045877680 @default.
• W1968925407 cites W2048797565 @default.
• W1968925407 cites W2051421702 @default.
• W1968925407 cites W2052024376 @default.
• W1968925407 cites W2055848305 @default.
• W1968925407 cites W2061118662 @default.
• W1968925407 cites W2069132215 @default.
• W1968925407 cites W2084460272 @default.
• W1968925407 cites W2088866343 @default.
• W1968925407 cites W2090191517 @default.
• W1968925407 cites W2096548270 @default.
• W1968925407 cites W2113679096 @default.
• W1968925407 cites W2130396250 @default.
• W1968925407 cites W2140527220 @default.
• W1968925407 cites W2144290967 @default.
• W1968925407 cites W2151913061 @default.
• W1968925407 cites W2315071131 @default.
• W1968925407 cites W2334588983 @default.
• W1968925407 cites W2396070378 @default.
• W1968925407 cites W4205407119 @default.
• W1968925407 cites W4293247451 @default.
• W1968925407 doi "https://doi.org/10.1016/j.biopha.2010.06.001" @default.
• W1968925407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20888175" @default.
• W1968925407 hasPublicationYear "2010" @default.
• W1968925407 type Work @default.
• W1968925407 sameAs 1968925407 @default.
• W1968925407 citedByCount "14" @default.
• W1968925407 countsByYear W19689254072013 @default.
• W1968925407 countsByYear W19689254072014 @default.
• W1968925407 countsByYear W19689254072015 @default.
• W1968925407 countsByYear W19689254072016 @default.
• W1968925407 countsByYear W19689254072020 @default.
• W1968925407 countsByYear W19689254072021 @default.
• W1968925407 countsByYear W19689254072023 @default.
• W1968925407 crossrefType "journal-article" @default.
• W1968925407 hasAuthorship W1968925407A5008387075 @default.
• W1968925407 hasAuthorship W1968925407A5058704454 @default.
• W1968925407 hasAuthorship W1968925407A5066017080 @default.
• W1968925407 hasAuthorship W1968925407A5066440800 @default.
• W1968925407 hasAuthorship W1968925407A5084761023 @default.
• W1968925407 hasConcept C126322002 @default.
• W1968925407 hasConcept C134018914 @default.
• W1968925407 hasConcept C144980905 @default.
• W1968925407 hasConcept C164705383 @default.
• W1968925407 hasConcept C170493617 @default.
• W1968925407 hasConcept C178853913 @default.
• W1968925407 hasConcept C2776885963 @default.
• W1968925407 hasConcept C2778122271 @default.
• W1968925407 hasConcept C2780114680 @default.
• W1968925407 hasConcept C2780393670 @default.
• W1968925407 hasConcept C2780886150 @default.
• W1968925407 hasConcept C42219234 @default.
• W1968925407 hasConcept C500558357 @default.
• W1968925407 hasConcept C541997718 @default.
• W1968925407 hasConcept C71924100 @default.
• W1968925407 hasConceptScore W1968925407C126322002 @default.
• W1968925407 hasConceptScore W1968925407C134018914 @default.
• W1968925407 hasConceptScore W1968925407C144980905 @default.
• W1968925407 hasConceptScore W1968925407C164705383 @default.
• W1968925407 hasConceptScore W1968925407C170493617 @default.
• W1968925407 hasConceptScore W1968925407C178853913 @default.
• W1968925407 hasConceptScore W1968925407C2776885963 @default.
• W1968925407 hasConceptScore W1968925407C2778122271 @default.
• W1968925407 hasConceptScore W1968925407C2780114680 @default.
• W1968925407 hasConceptScore W1968925407C2780393670 @default.
• W1968925407 hasConceptScore W1968925407C2780886150 @default.
• W1968925407 hasConceptScore W1968925407C42219234 @default.
• W1968925407 hasConceptScore W1968925407C500558357 @default.
• W1968925407 hasConceptScore W1968925407C541997718 @default.
• W1968925407 hasConceptScore W1968925407C71924100 @default.
• W1968925407 hasIssue "9" @default.
• W1968925407 hasLocation W19689254071 @default.
• W1968925407 hasLocation W19689254072 @default.
• W1968925407 hasOpenAccess W1968925407 @default.
• W1968925407 hasPrimaryLocation W19689254071 @default.
• W1968925407 hasRelatedWork W1968018935 @default.
• W1968925407 hasRelatedWork W2004835726 @default.

• next