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• W1968968207 abstract "This study sought to determine whether angiogenic blood vessels in disease models preferentially bind and internalize cationic liposomes injected intravenously. Angiogenesis was examined in pancreatic islet cell tumors of RIP-Tag2 transgenic mice and chronic airway inflammation in Mycoplasma pulmonis-infected C3H/HeNCr mice. For comparison, physiological angiogenesis was examined in normal mouse ovaries. We found that endothelial cells in all models avidly bound and internalized fluorescently labeled cationic liposomes (1,2-dioleoyl-3-trimethylammonium-propane [DOTAP]/cholesterol or dimethyldioctadecyl ammonium bromide [DDAB]/cholesterol) or liposome-DNA complexes. Confocal microscopic measurements showed that angiogenic endothelial cells averaged 15-33-fold more uptake than corresponding normal endothelial cells. Cationic liposome-DNA complexes were also avidly taken up, but anionic, neutral, or sterically stabilized neutral liposomes were not. Electron microscopic analysis showed that 32% of gold-labeled liposomes associated with tumor endothelial cells were adherent to the luminal surface, 53% were internalized into endosomes and multivesicular bodies, and 15% were extravascular 20 min after injection. Our findings indicate that angiogenic endothelial cells in these models avidly bind and internalize cationic liposomes and liposome-DNA complexes but not other types of liposomes. This preferential uptake raises the possibility of using cationic liposomes to target diagnostic or therapeutic agents selectively to angiogenic blood vessels in tumors and sites of chronic inflammation." @default.
• W1968968207 created "2016-06-24" @default.
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• W1968968207 date "1998-04-01" @default.
• W1968968207 modified "2023-10-18" @default.
• W1968968207 title "Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice." @default.
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• W1968968207 doi "https://doi.org/10.1172/jci965" @default.
• W1968968207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/508718" @default.
• W1968968207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9525983" @default.
• W1968968207 hasPublicationYear "1998" @default.
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