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- W1968973399 abstract "[Leu6,desGly-NH210]-LH-RH ethylamide and [Leu6]-LH-RH, two analogs of LH-RH, were prepared by the solid phase method. LH- and FSH-releasing activity of these peptides was assayed against LH-RH by subcutaneous administration in immature male rats. When the integrated levels of LH and FSH over a 6 hr period after the injection were used as parameter of the LH- and FSH-releasing activities, the [Leu6]-LH-RH showed LH-releasing activity of 9 times and FSH-releasing activity of 5 times greater than that of LH-RH. [Leu6,desGly-NH210]-LH-RH ethylamide showed LH- and FSH-releasing activities of 53.6 and 14.5 times greater, respectively, than that of LH-RH." @default.
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- W1968973399 date "1974-08-01" @default.
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- W1968973399 title "Synthesis and biological properties of [Leu-6]-LH-RH and [D-leu-6,desGly-NH210]-LH-RH ethylamide" @default.
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- W1968973399 doi "https://doi.org/10.1016/0006-291x(74)90445-8" @default.
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