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- W1968980267 abstract "Guanine-rich DNA telomeres occur at the 3’ ends of chromosomes. They can associate into four-stranded assemblies known as stacked G-4 quadruplexes. It has been found that the enzyme telomerase protects tumour cells but not normal cells from telomere loss during replication. Telomerase has therefore become an exciting new target for anti-cancer drug design. Small molecules which can stabilise the formation of G-4 quadruplexes may inhibit telomerase activity. We recently determined the crystal structure of the daunomycin complex with the telomeric sequence d(TGGGGT) [1]. We now report the 1.08 A structure of daunomycin complexed to d(GGGG). The crystals are tetragonal, space group I4, a = b = 40.21, c = 49.83 A. The final R is 16.1%. The asymmetric unit contains 2 independent strands of d(GGGG), 4 drug molecules, and eight Na and 2 Mg cations. The crystallographic 4-fold axis generates the biological unit which consists of 2 high-symmetry G-4 quadruplexes between which are 4 layers of daunomycin molecules with 4 daunomycins per layer." @default.
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- W1968980267 date "2005-08-23" @default.
- W1968980267 modified "2023-10-14" @default.
- W1968980267 title "A new highly symmetric DNA G-4 quadruplex/drug structure" @default.
- W1968980267 doi "https://doi.org/10.1107/s0108767305090690" @default.
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