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• W1968982342 endingPage "279" @default.
• W1968982342 startingPage "273" @default.
• W1968982342 abstract "Corynebacterium glutamicum, a gram-positive soil bacterium, has been used extensively for the industrial production of l-glutamate and other amino acids. In this study, an Escherichia coli–C. glutamicum shuttle expression plasmid harboring polyhydroxybutyrate (PHB) synthesis genes, phbCAB from Ralstonia eutropha, was constructed under the Ptrc promoter. C. glutamicum harboring this plasmid accumulated 3–13% PHB with a weight average molecular mass of 125,400 and a polydispersity of 11.3 when grown on glucose. PHB synthesis related enzyme activities including β-ketothiolase (PhbA), acetoacetyl-CoA reductase (PhbB) and PHB synthase (PhbC) were found to be constitutively produced independent of IPTG. l-Glutamate production increased 39–68% in two C. glutamicum strains harboring PHB synthesis genes compared with their parent strains in shake flask experiments. In fermentor studies, the recombinant produced approximately 23% more l-glutamate compared with that of the wild type, and yielded less intermediate metabolites or by-products including α-ketoglutarate, l-glutamine and lactate. These results suggested that the expression of phbCAB genes in C. glutamicum could help regulate glutamate production metabolism. This demonstrated that the expression of PHB synthesis genes has a positive effect on l-glutamate production in C. glutamicum." @default.
• W1968982342 created "2016-06-24" @default.
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• W1968982342 creator A5017175637 @default.
• W1968982342 creator A5021971429 @default.
• W1968982342 creator A5045659966 @default.
• W1968982342 date "2007-11-01" @default.
• W1968982342 modified "2023-10-17" @default.
• W1968982342 title "The impact of PHB accumulation on l-glutamate production by recombinant Corynebacterium glutamicum" @default.
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• W1968982342 doi "https://doi.org/10.1016/j.jbiotec.2007.03.014" @default.
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