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• W1968987074 abstract "The half-inhibition concentration (IC 50 ) of a drug indicates its ability to inhibit the binding of other ligands of a receptor. The authors used positron emission tomography to test the hypothesis that haloperidol's IC 50 toward the binding of tracer N-[ 11 C]methylspiperone ([ 11 C]NMSP) in brain must be increased in patients in whom more dopamine is bound to receptors than in healthy volunteers. The IC 50 of haloperidol was significantly elevated from 1.5 nmol/L in healthy volunteers and patients with bipolar disease without psychosis to 4.5 nmol/L in patients with schizophrenia or bipolar disease with psychosis. The higher IC 50 values in psychosis are consistent with an 8-fold increased binding of dopamine and a 16-fold elevated concentration of synaptic dopamine in psychosis. At the 80% haloperidol blockade of the receptors, the calculated amount of neurotransmitter bound in the patients with psychosis declined to twice the value estimated in the nonpsychotic subjects, that is, 5 pmol cm −3 ." @default.
• W1968987074 created "2016-06-24" @default.
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• W1968987074 date "2001-08-01" @default.
• W1968987074 modified "2023-09-27" @default.
• W1968987074 title "Quantification of Neuroreceptors in Living Human Brain. V. Endogenous Neurotransmitter Inhibition of Haloperidol Binding in Psychosis" @default.
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• W1968987074 doi "https://doi.org/10.1097/00004647-200108000-00011" @default.
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