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• W1968992495 abstract "Alpha toxin (AT) is the major virulence factor of Clostridium septicum that is a proteolytically activated pore-forming toxin that belongs to the aerolysin-like family of toxins. AT is predicted to be a three-domain molecule on the basis of its functional and sequence similarity with aerolysin, for which the crystal structure has been determined. In this study, we have substituted the entire primary structure of AT with alanine or cysteine to identify those amino acids that comprise functional domains involved in receptor binding, oligomerization, and pore formation. These studies revealed that receptor binding is restricted to domain 1 of the AT structure, whereas domains 1 and 3 are involved in oligomerization. These studies also revealed the presence of a putative functional region of AT proximal to the receptor-binding domain but distal from the pore-forming domain that is proposed to regulate the insertion of the transmembrane beta-hairpin of the prepore oligomer." @default.
• W1968992495 created "2016-06-24" @default.
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• W1968992495 date "2006-11-07" @default.
• W1968992495 modified "2023-10-17" @default.
• W1968992495 title "Identification of Functional Domains of <i>Clostridium septicum</i> Alpha Toxin" @default.
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• W1968992495 doi "https://doi.org/10.1021/bi061334p" @default.
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