Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969002889> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1969002889 endingPage "240A" @default.
- W1969002889 startingPage "240A" @default.
- W1969002889 abstract "Isolated thrombocytopenia following bone marrow transplantation was investigated in 65 fully grafted patients (pts) surviving 60 days post transplant. 24 pts (37%) developed this complication, which occurred most frequently in pts receiving pre-tx preparation with total body irradiation or busulfan. Two distinct syndromes were identified: (1) transient thrombocytopenia (9 pts) in which a normal platelet (plt) count (100,000/mm3) was established by day +40 but then fell to 10-45,000 on day +40-+70, with subsequent resolution by day +90. Three of these cases were associated with trimethoprim-sulfamethoxazole therapy. (2) chronic thrombocytopenia (15 pts) in which a plt count > 100,000 was not achieved at any time during the first 4 mo post-tx despite the simultaneous presence of normal granulocyte and reticulocyte counts. No association with drug therapy was detected. While the transient syndrome did not adversely affect prognosis, the chronic syndrome carried a high mortality (21% actuarial survival at 1000 days post-tx compared to 67% for all other pts p<0.01). The mortality was not due to bleeding but rather to a high association with both severe acute (grade III-IV) graft versus host disease and chronic GVHD. We conclude that isolated thrombocytopenia represents a significant complication of bone marrow transplantation particularly in pts receiving hematopoietic ablative preparatory regimens and that it is the chronic, and not the transient, thrombocytopenic syndrome that adversely affects patient prognosis as a manifestation of GVHD." @default.
- W1969002889 created "2016-06-24" @default.
- W1969002889 creator A5004296221 @default.
- W1969002889 creator A5005181711 @default.
- W1969002889 creator A5024304426 @default.
- W1969002889 creator A5045306382 @default.
- W1969002889 creator A5050365236 @default.
- W1969002889 creator A5065199181 @default.
- W1969002889 date "1984-04-01" @default.
- W1969002889 modified "2023-09-24" @default.
- W1969002889 title "ISOLATED THROMBOCYTOPENIA FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION" @default.
- W1969002889 doi "https://doi.org/10.1203/00006450-198404001-00880" @default.
- W1969002889 hasPublicationYear "1984" @default.
- W1969002889 type Work @default.
- W1969002889 sameAs 1969002889 @default.
- W1969002889 citedByCount "1" @default.
- W1969002889 crossrefType "journal-article" @default.
- W1969002889 hasAuthorship W1969002889A5004296221 @default.
- W1969002889 hasAuthorship W1969002889A5005181711 @default.
- W1969002889 hasAuthorship W1969002889A5024304426 @default.
- W1969002889 hasAuthorship W1969002889A5045306382 @default.
- W1969002889 hasAuthorship W1969002889A5050365236 @default.
- W1969002889 hasAuthorship W1969002889A5065199181 @default.
- W1969002889 hasBestOaLocation W19690028891 @default.
- W1969002889 hasConcept C126322002 @default.
- W1969002889 hasConcept C141071460 @default.
- W1969002889 hasConcept C2776694085 @default.
- W1969002889 hasConcept C2776755627 @default.
- W1969002889 hasConcept C2778880498 @default.
- W1969002889 hasConcept C2780007613 @default.
- W1969002889 hasConcept C2780611847 @default.
- W1969002889 hasConcept C2911091166 @default.
- W1969002889 hasConcept C71924100 @default.
- W1969002889 hasConcept C81182388 @default.
- W1969002889 hasConcept C89560881 @default.
- W1969002889 hasConcept C90924648 @default.
- W1969002889 hasConceptScore W1969002889C126322002 @default.
- W1969002889 hasConceptScore W1969002889C141071460 @default.
- W1969002889 hasConceptScore W1969002889C2776694085 @default.
- W1969002889 hasConceptScore W1969002889C2776755627 @default.
- W1969002889 hasConceptScore W1969002889C2778880498 @default.
- W1969002889 hasConceptScore W1969002889C2780007613 @default.
- W1969002889 hasConceptScore W1969002889C2780611847 @default.
- W1969002889 hasConceptScore W1969002889C2911091166 @default.
- W1969002889 hasConceptScore W1969002889C71924100 @default.
- W1969002889 hasConceptScore W1969002889C81182388 @default.
- W1969002889 hasConceptScore W1969002889C89560881 @default.
- W1969002889 hasConceptScore W1969002889C90924648 @default.
- W1969002889 hasLocation W19690028891 @default.
- W1969002889 hasOpenAccess W1969002889 @default.
- W1969002889 hasPrimaryLocation W19690028891 @default.
- W1969002889 hasRelatedWork W2049808065 @default.
- W1969002889 hasRelatedWork W2088702094 @default.
- W1969002889 hasRelatedWork W2091710908 @default.
- W1969002889 hasRelatedWork W2131188876 @default.
- W1969002889 hasRelatedWork W2402227730 @default.
- W1969002889 hasRelatedWork W2435305444 @default.
- W1969002889 hasRelatedWork W2462048819 @default.
- W1969002889 hasRelatedWork W2502040819 @default.
- W1969002889 hasRelatedWork W2529889366 @default.
- W1969002889 hasRelatedWork W2560002354 @default.
- W1969002889 hasVolume "18" @default.
- W1969002889 isParatext "false" @default.
- W1969002889 isRetracted "false" @default.
- W1969002889 magId "1969002889" @default.
- W1969002889 workType "article" @default.