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- W1969007191 abstract "Inside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a conserved RNA interference (RNAi) pathway which leads to specific degradation of complementary target mRNAs through base-pairing recognition. As with other viruses, studies have shown that replication of the HIV-1 in cultured cells can be targeted and inhibited by synthetic siRNAs. The relative ease of siRNA design and the versatility of RNAi to target a broad spectrum of mRNAs have led to the promise that drug discovery in the RNAi pathway could be effective against pathogens. This review discusses the current experimental principles that guide the application of RNAi against HIV and describes challenges and limitations that need to be surmounted in order for siRNAs to become practical antiviral drugs. The practical use of RNAi therapy for HIV infection will depend on overcoming several challenges, including the ability to establish long-term expression of siRNA without off-target effects and the capacity to counteract mutant escape viruses." @default.
- W1969007191 created "2016-06-24" @default.
- W1969007191 creator A5019747527 @default.
- W1969007191 creator A5080524336 @default.
- W1969007191 creator A5087036578 @default.
- W1969007191 date "2007-01-01" @default.
- W1969007191 modified "2023-10-10" @default.
- W1969007191 title "RNAi Therapy for HIV Infection" @default.
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- W1969007191 doi "https://doi.org/10.2165/00063030-200721010-00003" @default.
- W1969007191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7100089" @default.
- W1969007191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17263586" @default.
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