Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969007811> ?p ?o ?g. }
- W1969007811 endingPage "48" @default.
- W1969007811 startingPage "48" @default.
- W1969007811 abstract "Hepatitis B virus (HBV) infections play an important role in the development of hepatocellular carcinoma (HCC). HBV X protein (HBx) is a multifunctional protein that can modulate various cellular processes and plays a crucial role in the pathogenesis of HCC. HBx is known to interact with DNA helicase components of TFIIH, a basal transcriptional factor and an integral component of DNA excision repair.In this study, the functional relevance of this association was further investigated in the context to DNA repair. By site-directed mutagenesis HBx's critical residues for interaction with TFIIH were identified. Similarly, TFIIH mutants lacking ATPase domain and the conserved carboxyl-terminal domain failed to interact with HBx. Yeast and mammalian cells expressing HBx(wt) conferred hypersensitivity to UV irradiation, which is interpreted as a basic deficiency in nucleotide excision repair. HBx(mut120) (Glu to Val) was defective in binding to TFIIH and failed to respond to UV.We conclude that HBx may act as the promoting factor by inhibiting DNA repair causing DNA damage and accumulation of errors, thereby contributing to HCC development." @default.
- W1969007811 created "2016-06-24" @default.
- W1969007811 creator A5000738166 @default.
- W1969007811 creator A5008301626 @default.
- W1969007811 creator A5079947086 @default.
- W1969007811 date "2011-01-01" @default.
- W1969007811 modified "2023-09-25" @default.
- W1969007811 title "Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH" @default.
- W1969007811 cites W1531635740 @default.
- W1969007811 cites W1827435162 @default.
- W1969007811 cites W1966460436 @default.
- W1969007811 cites W1967705712 @default.
- W1969007811 cites W1972224434 @default.
- W1969007811 cites W1977541068 @default.
- W1969007811 cites W1978922109 @default.
- W1969007811 cites W1981651251 @default.
- W1969007811 cites W1985022589 @default.
- W1969007811 cites W1986150533 @default.
- W1969007811 cites W1987536971 @default.
- W1969007811 cites W1987764628 @default.
- W1969007811 cites W1988525857 @default.
- W1969007811 cites W1992082799 @default.
- W1969007811 cites W2001537654 @default.
- W1969007811 cites W2001600181 @default.
- W1969007811 cites W2005186431 @default.
- W1969007811 cites W2005790594 @default.
- W1969007811 cites W2007208208 @default.
- W1969007811 cites W2012793203 @default.
- W1969007811 cites W2024421793 @default.
- W1969007811 cites W2032781689 @default.
- W1969007811 cites W2034116029 @default.
- W1969007811 cites W2038625938 @default.
- W1969007811 cites W2038940861 @default.
- W1969007811 cites W2039068784 @default.
- W1969007811 cites W2043688946 @default.
- W1969007811 cites W2045809602 @default.
- W1969007811 cites W2049353359 @default.
- W1969007811 cites W2052180464 @default.
- W1969007811 cites W2052553540 @default.
- W1969007811 cites W2054926531 @default.
- W1969007811 cites W2056570769 @default.
- W1969007811 cites W2057211093 @default.
- W1969007811 cites W2058264480 @default.
- W1969007811 cites W2058349670 @default.
- W1969007811 cites W2062687382 @default.
- W1969007811 cites W2071096096 @default.
- W1969007811 cites W2071499648 @default.
- W1969007811 cites W2072434768 @default.
- W1969007811 cites W2075574964 @default.
- W1969007811 cites W2076962190 @default.
- W1969007811 cites W2077485054 @default.
- W1969007811 cites W2078633971 @default.
- W1969007811 cites W2079715135 @default.
- W1969007811 cites W2081472291 @default.
- W1969007811 cites W2084359455 @default.
- W1969007811 cites W2087085064 @default.
- W1969007811 cites W2089712104 @default.
- W1969007811 cites W2093019351 @default.
- W1969007811 cites W2097183131 @default.
- W1969007811 cites W2106219490 @default.
- W1969007811 cites W2114036798 @default.
- W1969007811 cites W2119882170 @default.
- W1969007811 cites W2122268699 @default.
- W1969007811 cites W2129749984 @default.
- W1969007811 cites W2130262444 @default.
- W1969007811 cites W2131203018 @default.
- W1969007811 cites W2142466677 @default.
- W1969007811 cites W2147794206 @default.
- W1969007811 cites W2149316054 @default.
- W1969007811 cites W2168320283 @default.
- W1969007811 cites W2170564800 @default.
- W1969007811 cites W2170992955 @default.
- W1969007811 cites W2173751778 @default.
- W1969007811 cites W2327798355 @default.
- W1969007811 doi "https://doi.org/10.1186/1471-2180-11-48" @default.
- W1969007811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3060106" @default.
- W1969007811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21375739" @default.
- W1969007811 hasPublicationYear "2011" @default.
- W1969007811 type Work @default.
- W1969007811 sameAs 1969007811 @default.
- W1969007811 citedByCount "36" @default.
- W1969007811 countsByYear W19690078112012 @default.
- W1969007811 countsByYear W19690078112013 @default.
- W1969007811 countsByYear W19690078112014 @default.
- W1969007811 countsByYear W19690078112015 @default.
- W1969007811 countsByYear W19690078112016 @default.
- W1969007811 countsByYear W19690078112018 @default.
- W1969007811 countsByYear W19690078112019 @default.
- W1969007811 countsByYear W19690078112020 @default.
- W1969007811 countsByYear W19690078112021 @default.
- W1969007811 countsByYear W19690078112022 @default.
- W1969007811 crossrefType "journal-article" @default.
- W1969007811 hasAuthorship W1969007811A5000738166 @default.
- W1969007811 hasAuthorship W1969007811A5008301626 @default.
- W1969007811 hasAuthorship W1969007811A5079947086 @default.
- W1969007811 hasBestOaLocation W19690078111 @default.
- W1969007811 hasConcept C104317684 @default.
- W1969007811 hasConcept C104451858 @default.