FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969011638> ?p ?o ?g. }

• W1969011638 endingPage "373" @default.
• W1969011638 startingPage "366" @default.
• W1969011638 abstract "The 19-kDa C-terminal region of merozoite surface protein 1 (MSP1(19)), a major blood stage malaria vaccine candidate, is the target of cellular and humoral immune responses in humans naturally infected with Plasmodium falciparum. We have previously described engineered variants of this protein, designed to be better vaccine candidates, but the human immune response to these proteins has not been characterized fully. Here we have investigated the antigenicity of one such variant compared to wild-type MSP1(19)-derived protein and peptides. Gambian adults produced both high T helper type 1 (Th1) [interferon (IFN)-γ] and Th0/Th2 [interleukin (IL)-13 and sCD30] responses to the wild-type MSP1(19) and the modified protein as wells as to peptides derived from both forms. Response to the modified MSP1(19) (with three amino acid substitutions: Glu27Tyr, Leu31Arg and Glu43Leu) relative to the wild-type, included higher IFN-γ production. Interestingly, some peptides evoked different patterns of cytokine responses. Modified peptides induced higher IL-13 production than the wild-type, while the conserved peptides P16 and P19 induced the highest IFN-γ and IL-13 and/or sCD30 release, respectively. We identified P16 as the immunodominant peptide that was recognized by cells from 63% of the study population, and not restricted to any particular human leucocyte antigen D-related (HLA-DR) type. These findings provide new and very useful information for future vaccine development and formulation as well as potential Th1/Th2 immunmodulation using either wild-type or modified protein in combination with their peptides." @default.
• W1969011638 created "2016-06-24" @default.
• W1969011638 creator A5001952688 @default.
• W1969011638 creator A5044870525 @default.
• W1969011638 creator A5046686960 @default.
• W1969011638 creator A5067859289 @default.
• W1969011638 creator A5076699881 @default.
• W1969011638 creator A5089616725 @default.
• W1969011638 date "2011-11-08" @default.
• W1969011638 modified "2023-10-10" @default.
• W1969011638 title "An engineered<i>Plasmodium falciparum</i>C-terminal 19-kilodalton merozoite surface protein 1 vaccine candidate induces high levels of interferon-gamma production associated with cellular immune responses to specific peptide sequences in Gambian adults naturally exposed to malaria" @default.
• W1969011638 cites W1588700076 @default.
• W1969011638 cites W1941463571 @default.
• W1969011638 cites W1979346865 @default.
• W1969011638 cites W1989672476 @default.
• W1969011638 cites W2005843225 @default.
• W1969011638 cites W2006217355 @default.
• W1969011638 cites W2052944434 @default.
• W1969011638 cites W2062519861 @default.
• W1969011638 cites W2062972555 @default.
• W1969011638 cites W2084498664 @default.
• W1969011638 cites W2089035318 @default.
• W1969011638 cites W2092924223 @default.
• W1969011638 cites W2096354903 @default.
• W1969011638 cites W2097397635 @default.
• W1969011638 cites W2103830958 @default.
• W1969011638 cites W2103990301 @default.
• W1969011638 cites W2117003890 @default.
• W1969011638 cites W2126137101 @default.
• W1969011638 cites W2127357344 @default.
• W1969011638 cites W2135480771 @default.
• W1969011638 cites W2165583797 @default.
• W1969011638 doi "https://doi.org/10.1111/j.1365-2249.2011.04467.x" @default.
• W1969011638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3232385" @default.
• W1969011638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22059995" @default.
• W1969011638 hasPublicationYear "2011" @default.
• W1969011638 type Work @default.
• W1969011638 sameAs 1969011638 @default.
• W1969011638 citedByCount "3" @default.
• W1969011638 countsByYear W19690116382014 @default.
• W1969011638 countsByYear W19690116382015 @default.
• W1969011638 crossrefType "journal-article" @default.
• W1969011638 hasAuthorship W1969011638A5001952688 @default.
• W1969011638 hasAuthorship W1969011638A5044870525 @default.
• W1969011638 hasAuthorship W1969011638A5046686960 @default.
• W1969011638 hasAuthorship W1969011638A5067859289 @default.
• W1969011638 hasAuthorship W1969011638A5076699881 @default.
• W1969011638 hasAuthorship W1969011638A5089616725 @default.
• W1969011638 hasBestOaLocation W19690116381 @default.
• W1969011638 hasConcept C147483822 @default.
• W1969011638 hasConcept C159047783 @default.
• W1969011638 hasConcept C195616568 @default.
• W1969011638 hasConcept C203014093 @default.
• W1969011638 hasConcept C2777023991 @default.
• W1969011638 hasConcept C2778048844 @default.
• W1969011638 hasConcept C2778371730 @default.
• W1969011638 hasConcept C2778690821 @default.
• W1969011638 hasConcept C2779026604 @default.
• W1969011638 hasConcept C2780841837 @default.
• W1969011638 hasConcept C2781034427 @default.
• W1969011638 hasConcept C2908647359 @default.
• W1969011638 hasConcept C71924100 @default.
• W1969011638 hasConcept C86803240 @default.
• W1969011638 hasConcept C8891405 @default.
• W1969011638 hasConcept C99454951 @default.
• W1969011638 hasConceptScore W1969011638C147483822 @default.
• W1969011638 hasConceptScore W1969011638C159047783 @default.
• W1969011638 hasConceptScore W1969011638C195616568 @default.
• W1969011638 hasConceptScore W1969011638C203014093 @default.
• W1969011638 hasConceptScore W1969011638C2777023991 @default.
• W1969011638 hasConceptScore W1969011638C2778048844 @default.
• W1969011638 hasConceptScore W1969011638C2778371730 @default.
• W1969011638 hasConceptScore W1969011638C2778690821 @default.
• W1969011638 hasConceptScore W1969011638C2779026604 @default.
• W1969011638 hasConceptScore W1969011638C2780841837 @default.
• W1969011638 hasConceptScore W1969011638C2781034427 @default.
• W1969011638 hasConceptScore W1969011638C2908647359 @default.
• W1969011638 hasConceptScore W1969011638C71924100 @default.
• W1969011638 hasConceptScore W1969011638C86803240 @default.
• W1969011638 hasConceptScore W1969011638C8891405 @default.
• W1969011638 hasConceptScore W1969011638C99454951 @default.
• W1969011638 hasIssue "3" @default.
• W1969011638 hasLocation W19690116381 @default.
• W1969011638 hasLocation W19690116382 @default.
• W1969011638 hasLocation W19690116383 @default.
• W1969011638 hasOpenAccess W1969011638 @default.
• W1969011638 hasPrimaryLocation W19690116381 @default.
• W1969011638 hasRelatedWork W1966221413 @default.
• W1969011638 hasRelatedWork W1970914759 @default.
• W1969011638 hasRelatedWork W2013185869 @default.
• W1969011638 hasRelatedWork W2015243764 @default.
• W1969011638 hasRelatedWork W2020764495 @default.
• W1969011638 hasRelatedWork W2083971605 @default.
• W1969011638 hasRelatedWork W2119076403 @default.
• W1969011638 hasRelatedWork W2146994826 @default.
• W1969011638 hasRelatedWork W2340524139 @default.
• W1969011638 hasRelatedWork W3134240677 @default.
• W1969011638 hasVolume "166" @default.

• next