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- W1969028081 abstract "Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's Disease (AD). When AChE is inhibited, more acetylcholine is available in the synaptic cleft, resulting in an improvement of cognitive function. Although the therapy with AChE inhibitors (AChEI) is considered to be only symptomatic, these medications are still the first choice for treating AD patients in early stages of the disease. In this study, methanolic, dichloromethane and aqueous crude extracts from 84 Traditional Chinese Medical (TCM) plants were tested for in vitro anti-acetylcholinesterase activity based on Ellman's colorimetric assay. Identity of the plants was assured by DNA barcoding. Thin layer chromatography (TLC) and mass spectrometry (MS) were performed to gain a first insight into the chemical compounds of the TCM plant extracts used. Five TCM plants showed a strong inhibitory activity of AChE. Extracts from Coptis spp., Capsella bursa-pastoris, Mahonia baelei, Phellodendron spp. and Polygonum multiflorum exhibited a distinctive AChE inhibition with Mahonia bealei and Phellodendron spp. featuring this inhibitory activity in all three extracts. Seven of these TCM plant extracts exhibited EC50 values ranging from 0.021 μg/ml to 8.7 μg/ml, therefore showing a stronger AChE inhibition than the already known AChEI galanthamine (EC50 = 51.1 μg/ml). These findings suggest that Traditional Chinese Medical plants represent an important source of natural compounds that affect the activity of AChE, which might be interesting drug candidates to slow down the progression of AD." @default.
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- W1969028081 date "2010-07-01" @default.
- W1969028081 modified "2023-09-27" @default.
- W1969028081 title "O4-01-05: Inhibition of acetylcholinesterase by traditional Chinese medical plants: A new source of potential drugs for treating Alzheimer's disease" @default.
- W1969028081 doi "https://doi.org/10.1016/j.jalz.2010.05.469" @default.
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