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• W1969033718 abstract "gp34, which we had identified as a target molecule of the trans-activation by Tax of human T-cell leukemia virus type I (HTLV-I), has been found to bind OX40, a member of the tumor necrosis factor receptor family, resulting in growth stimulation of activated T cells. We here demonstrate that not only gp34 (OX40L), but also OX40 can be transcriptionally activated by Tax. Three Tax-producing human T-cell lines carrying the HTLV-I genome expressed OX40 on their surfaces. Furthermore, Tax-induced transcriptional activation of OX40 was shown in Tax-inducible JPX-9 cells. These results demonstrate that both OX40 and its ligand (gp34) are constitutively expressed on the surfaces of Tax-expressing T lymphocytes, suggesting that the OX40L/OX40 system contributes to growth stimulation of the virus-infected T cells." @default.
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• W1969033718 date "1996-03-01" @default.
• W1969033718 modified "2023-10-16" @default.
• W1969033718 title "Induction of OX40, a Receptor of gp34, on T Cells by Trans-acting Transcriptional Activator, Tax, of Human T-Cell Leukemia Virus Type I" @default.
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• W1969033718 doi "https://doi.org/10.1111/j.1349-7006.1996.tb00210.x" @default.
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