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- W1969037815 abstract "Summary Activin A is a multi-functional cytokine with a potent stimulation on erythroid cell differentiation in the bone marrow. The actions of activin A are determined by a balance of the levels of activin A and its inhibitor, follistatin (FS). However, the regulation of its actions in the bone marrow has been unclear. Here we show that bone marrow-derived stromal fibroblasts are the major source of activin A and FS in the bone marrow, and that the production of activin A is enhanced by interleukin-1β (IL-1β) and lipopolysaccharide (LPS), whereas interferon-γ (IFN-γ) inhibits the secretion of activin A by stromal fibroblasts. Concomitantly, IL-1β as well as LPS inhibits and IFN-γ stimulates FS secretion from stromal fibroblasts. Thus, these cytokines potently regulate activin A actions by reciprocal modulation of activin A and FS secretion from stromal fibroblasts. Because activin A exhibits anti-inflammatory effects in various tissues, up-regulation of activin A actions by IL-1β and endotoxin in the bone marrow may play a protective role against inflammatory processes as well as anaemia. The present results also suggest that the inhibitory effect of IFN-γ on erythropoiesis is mediated at least in part by a suppression of activin A actions in bone marrow." @default.
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- W1969037815 date "2001-10-01" @default.
- W1969037815 modified "2023-09-26" @default.
- W1969037815 title "Interleukin-1 <i>β</i> enhances and interferon-<i>γ</i> suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts" @default.
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- W1969037815 doi "https://doi.org/10.1046/j.1365-2249.2001.01644.x" @default.
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