FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969040282> ?p ?o ?g. }

• W1969040282 endingPage "373" @default.
• W1969040282 startingPage "366" @default.
• W1969040282 abstract "Since Unna's Abtropfung hypothesis, the process of migration of nevus cells in the dermis remains unknown. To investigate its mechanisms, we studied the role of gelatinases in dermal nevus cells obtained from congenital pigmented nevi, which are major actors in the remodeling of basement membrane proteins. Our previous studies have shown that dermal nevus cells express pro-matrix metalloproteinase (MMP)-2 exclusively and cannot return to the dermis when seeded together with keratinocytes on top of the dermis in a skin reconstruction model. To examine why MMP-2 was not in its active form, we used Western blot to study the expression of members of the MMP-2 activation pathway (membrane type 1-MMP and tissue inhibitor of metalloproteinase-2), which proved to be normally expressed. To induce the dermal passage of nevus cells artificially, we also tried to activate gelatinases with phorbol-12-myristate-13-acetate and epidermal growth factor, using epidermis reconstructed with nevus cells. No migration in the dermis could be triggered. We conclude that the absence of active MMP-2 is due to a functional blockade of its activation pathway and may prevent dermal nevus cells from reaching the dermal compartment in skin reconstructs. Furthermore, our findings reinforce the concept that dermal nevus cells originating from congenital nevi are in a quiescent status." @default.
• W1969040282 created "2016-06-24" @default.
• W1969040282 creator A5008823637 @default.
• W1969040282 creator A5029864290 @default.
• W1969040282 creator A5042029731 @default.
• W1969040282 creator A5042296138 @default.
• W1969040282 creator A5059597997 @default.
• W1969040282 creator A5076910969 @default.
• W1969040282 date "2003-07-15" @default.
• W1969040282 modified "2023-10-17" @default.
• W1969040282 title "The ‘Abtropfung Phenomenon’ Revisited: Dermal Nevus Cells from Congenital Nevi Cannot Activate Matrix Metalloproteinase 2 (MMP-2)" @default.
• W1969040282 cites W1501988955 @default.
• W1969040282 cites W1548720861 @default.
• W1969040282 cites W1950892959 @default.
• W1969040282 cites W1964134603 @default.
• W1969040282 cites W1968785754 @default.
• W1969040282 cites W1979390430 @default.
• W1969040282 cites W1979912640 @default.
• W1969040282 cites W1988804288 @default.
• W1969040282 cites W1988806762 @default.
• W1969040282 cites W2013524931 @default.
• W1969040282 cites W2020973067 @default.
• W1969040282 cites W2024024936 @default.
• W1969040282 cites W2038472306 @default.
• W1969040282 cites W2040139982 @default.
• W1969040282 cites W2041768004 @default.
• W1969040282 cites W2043068076 @default.
• W1969040282 cites W2043335448 @default.
• W1969040282 cites W2048996380 @default.
• W1969040282 cites W2049220062 @default.
• W1969040282 cites W2049327035 @default.
• W1969040282 cites W2052638358 @default.
• W1969040282 cites W2055731498 @default.
• W1969040282 cites W2059919196 @default.
• W1969040282 cites W2062819670 @default.
• W1969040282 cites W2063284185 @default.
• W1969040282 cites W2064505857 @default.
• W1969040282 cites W2066445905 @default.
• W1969040282 cites W2068289276 @default.
• W1969040282 cites W2069357408 @default.
• W1969040282 cites W2069951758 @default.
• W1969040282 cites W2072694858 @default.
• W1969040282 cites W2074005418 @default.
• W1969040282 cites W2076718353 @default.
• W1969040282 cites W2078567932 @default.
• W1969040282 cites W2080527699 @default.
• W1969040282 cites W2082892212 @default.
• W1969040282 cites W2084975988 @default.
• W1969040282 cites W2085766409 @default.
• W1969040282 cites W2095521632 @default.
• W1969040282 cites W2100937896 @default.
• W1969040282 cites W2121492332 @default.
• W1969040282 cites W2128049766 @default.
• W1969040282 cites W2144763197 @default.
• W1969040282 cites W2147504789 @default.
• W1969040282 cites W2401653153 @default.
• W1969040282 cites W4250908540 @default.
• W1969040282 doi "https://doi.org/10.1034/j.1600-0749.2003.00058.x" @default.
• W1969040282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12859620" @default.
• W1969040282 hasPublicationYear "2003" @default.
• W1969040282 type Work @default.
• W1969040282 sameAs 1969040282 @default.
• W1969040282 citedByCount "12" @default.
• W1969040282 countsByYear W19690402822012 @default.
• W1969040282 countsByYear W19690402822014 @default.
• W1969040282 countsByYear W19690402822020 @default.
• W1969040282 countsByYear W19690402822021 @default.
• W1969040282 crossrefType "journal-article" @default.
• W1969040282 hasAuthorship W1969040282A5008823637 @default.
• W1969040282 hasAuthorship W1969040282A5029864290 @default.
• W1969040282 hasAuthorship W1969040282A5042029731 @default.
• W1969040282 hasAuthorship W1969040282A5042296138 @default.
• W1969040282 hasAuthorship W1969040282A5059597997 @default.
• W1969040282 hasAuthorship W1969040282A5076910969 @default.
• W1969040282 hasConcept C105702510 @default.
• W1969040282 hasConcept C109523444 @default.
• W1969040282 hasConcept C142724271 @default.
• W1969040282 hasConcept C185592680 @default.
• W1969040282 hasConcept C2776193487 @default.
• W1969040282 hasConcept C2776232661 @default.
• W1969040282 hasConcept C2776458125 @default.
• W1969040282 hasConcept C2777624698 @default.
• W1969040282 hasConcept C2777658100 @default.
• W1969040282 hasConcept C2779323059 @default.
• W1969040282 hasConcept C2910246616 @default.
• W1969040282 hasConcept C502942594 @default.
• W1969040282 hasConcept C55493867 @default.
• W1969040282 hasConcept C71924100 @default.
• W1969040282 hasConcept C86803240 @default.
• W1969040282 hasConceptScore W1969040282C105702510 @default.
• W1969040282 hasConceptScore W1969040282C109523444 @default.
• W1969040282 hasConceptScore W1969040282C142724271 @default.
• W1969040282 hasConceptScore W1969040282C185592680 @default.
• W1969040282 hasConceptScore W1969040282C2776193487 @default.
• W1969040282 hasConceptScore W1969040282C2776232661 @default.
• W1969040282 hasConceptScore W1969040282C2776458125 @default.
• W1969040282 hasConceptScore W1969040282C2777624698 @default.
• W1969040282 hasConceptScore W1969040282C2777658100 @default.

• next