FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969049744> ?p ?o ?g. }

• W1969049744 endingPage "1818" @default.
• W1969049744 startingPage "1809" @default.
• W1969049744 abstract "Summary Background Mast cell degranulation is believed to act as a key event in initiating and maintaining airway response to allergen challenge in human asthma. It is hypothesized that the mast cell may play a similar role in equine heaves, which shares many similarities with occupational dust‐induced asthma. Objective The aim of this study was to quantify the mast cell proteinase tryptase in bronchoalveolar lavage fluid (BALF) from control and heaves‐susceptible horses and to investigate tryptase mRNA and protein expression in pulmonary mast cells. Methods Equine BALF tryptase concentrations were determined by ELISA from control and heaves‐susceptible horses pre and post 24 h hay/straw challenge (HSC). Tryptase mRNA and protein expression were investigated by quantitative PCR and immunohistochemistry in bronchial and bronchiolar tissue samples of control and heaves‐susceptible horses. Results Both control and heaves‐susceptible horses had significantly increased BALF tryptase concentrations following HSC ( P =0.003 and 0.034, respectively). Increased numbers of tryptase‐expressing intra‐epithelial mast cells were demonstrated in heaves horses, but not controls, following challenge ( P =0.02). Bronchiolar tissue from heaves horses removed from challenge contained significantly lower tryptase transcripts than that from control horses ( P =0.02). Conclusion Mast cell degranulation and tryptase release into the airways occur following HSC of control and heaves‐susceptible horses. The greater number of mast cells available in the bronchiolar epithelium of heaves horses may be clinically significant in the pulmonary inflammatory response of heaves." @default.
• W1969049744 created "2016-06-24" @default.
• W1969049744 creator A5009321593 @default.
• W1969049744 creator A5016934978 @default.
• W1969049744 creator A5022630690 @default.
• W1969049744 creator A5023118281 @default.
• W1969049744 creator A5032467053 @default.
• W1969049744 creator A5046046248 @default.
• W1969049744 creator A5080726169 @default.
• W1969049744 creator A5087534292 @default.
• W1969049744 creator A5090311732 @default.
• W1969049744 date "2007-10-23" @default.
• W1969049744 modified "2023-10-15" @default.
• W1969049744 title "Organic dust exposure increases mast cell tryptase in bronchoalveolar lavage fluid and airway epithelium of heaves horses" @default.
• W1969049744 cites W1748543015 @default.
• W1969049744 cites W1963773983 @default.
• W1969049744 cites W1963992704 @default.
• W1969049744 cites W1972281305 @default.
• W1969049744 cites W1979934998 @default.
• W1969049744 cites W1981049346 @default.
• W1969049744 cites W1987240145 @default.
• W1969049744 cites W1995077996 @default.
• W1969049744 cites W2009256230 @default.
• W1969049744 cites W2013506651 @default.
• W1969049744 cites W2023430605 @default.
• W1969049744 cites W2036674363 @default.
• W1969049744 cites W2037064714 @default.
• W1969049744 cites W2039252747 @default.
• W1969049744 cites W2045087493 @default.
• W1969049744 cites W2045577652 @default.
• W1969049744 cites W2061998739 @default.
• W1969049744 cites W2072557317 @default.
• W1969049744 cites W2080195509 @default.
• W1969049744 cites W2081592351 @default.
• W1969049744 cites W2082995747 @default.
• W1969049744 cites W2089286909 @default.
• W1969049744 cites W2096584793 @default.
• W1969049744 cites W2098419353 @default.
• W1969049744 cites W2103983530 @default.
• W1969049744 cites W2122818275 @default.
• W1969049744 cites W2129028964 @default.
• W1969049744 cites W2129739756 @default.
• W1969049744 cites W2146050924 @default.
• W1969049744 cites W2154945180 @default.
• W1969049744 cites W2159556499 @default.
• W1969049744 cites W2167023526 @default.
• W1969049744 cites W2172222179 @default.
• W1969049744 cites W2270046134 @default.
• W1969049744 cites W2283898964 @default.
• W1969049744 cites W2302881494 @default.
• W1969049744 cites W2437344816 @default.
• W1969049744 cites W59008486 @default.
• W1969049744 doi "https://doi.org/10.1111/j.1365-2222.2007.02857.x" @default.
• W1969049744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17956586" @default.
• W1969049744 hasPublicationYear "2007" @default.
• W1969049744 type Work @default.
• W1969049744 sameAs 1969049744 @default.
• W1969049744 citedByCount "19" @default.
• W1969049744 countsByYear W19690497442015 @default.
• W1969049744 countsByYear W19690497442016 @default.
• W1969049744 countsByYear W19690497442019 @default.
• W1969049744 countsByYear W19690497442020 @default.
• W1969049744 countsByYear W19690497442022 @default.
• W1969049744 countsByYear W19690497442023 @default.
• W1969049744 crossrefType "journal-article" @default.
• W1969049744 hasAuthorship W1969049744A5009321593 @default.
• W1969049744 hasAuthorship W1969049744A5016934978 @default.
• W1969049744 hasAuthorship W1969049744A5022630690 @default.
• W1969049744 hasAuthorship W1969049744A5023118281 @default.
• W1969049744 hasAuthorship W1969049744A5032467053 @default.
• W1969049744 hasAuthorship W1969049744A5046046248 @default.
• W1969049744 hasAuthorship W1969049744A5080726169 @default.
• W1969049744 hasAuthorship W1969049744A5087534292 @default.
• W1969049744 hasAuthorship W1969049744A5090311732 @default.
• W1969049744 hasBestOaLocation W19690497441 @default.
• W1969049744 hasConcept C126322002 @default.
• W1969049744 hasConcept C142724271 @default.
• W1969049744 hasConcept C151730666 @default.
• W1969049744 hasConcept C170493617 @default.
• W1969049744 hasConcept C203014093 @default.
• W1969049744 hasConcept C2777714996 @default.
• W1969049744 hasConcept C2777961210 @default.
• W1969049744 hasConcept C2779726688 @default.
• W1969049744 hasConcept C2780614898 @default.
• W1969049744 hasConcept C2780762169 @default.
• W1969049744 hasConcept C2781406822 @default.
• W1969049744 hasConcept C49802076 @default.
• W1969049744 hasConcept C71924100 @default.
• W1969049744 hasConcept C86803240 @default.
• W1969049744 hasConceptScore W1969049744C126322002 @default.
• W1969049744 hasConceptScore W1969049744C142724271 @default.
• W1969049744 hasConceptScore W1969049744C151730666 @default.
• W1969049744 hasConceptScore W1969049744C170493617 @default.
• W1969049744 hasConceptScore W1969049744C203014093 @default.
• W1969049744 hasConceptScore W1969049744C2777714996 @default.
• W1969049744 hasConceptScore W1969049744C2777961210 @default.
• W1969049744 hasConceptScore W1969049744C2779726688 @default.
• W1969049744 hasConceptScore W1969049744C2780614898 @default.

• next