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• W1969052017 abstract "To determine the effects of local bone turnover on the migration of macroporous hydroxyapatite onlays in the nasal bone and mandibular ramus, we performed histomorphometric analyses of the underlying bone area in 41 New Zealand White rabbits from the age of 4 weeks. The hydroxyapatite implants were placed under the periosteum of the right nasal bone (a depository bone onto its periosteal surface and endosteal resorptive) and the mandibular ramus (resorptive onto its outer surface). The corresponding left sides were sham operated. Following fluorescence bone labeling, composite specimens of the hydroxyapatite block including both sides of the nasal bone and mandible were removed at 0 (n = 1), 3, 6, 9, 12, and 16 weeks postoperatively (n = 8, respectively) and processed to yield undecalcified sections. Bone-bone marrow interfaces in the entire area within 200 microns beneath the base of the hydroxyapatite and in the counter-area on the sham-operated side were measured under a light microscope. In all grafted specimens, the hydroxyapatite matrix was directly united with the underlying tissue by bone ingrowth. However, the sinking of the hydroxyapatite graft in the nasal bone was significant at 3 weeks postoperatively and gradually increased thereafter. In the mandible, the sinking became significant at 6 weeks. In the nasal bone, the bone area density beneath the graft showed a time-dependent decrease during the experimental period, but in the mandibular bone, the value was initially decreased at 3 weeks and then recovered to baseline level. In both bones, parameters of bone resorption, such as osteoclast number and osteoclast surface, were significantly increased from 3 weeks. While the parameters of bone formation, such as osteoblast surface and mineralizing surface, were significantly decreased from 3 weeks in the nasal bone, they were significantly increased in the mandible. Mineral apposition rate showed a significant decrease in both bones. Our data indicate that while the bone area density beneath the hydroxyapatite seemed to depend on bone formation, increased bone resorption would be more critical for the remodeling of underlying bony architecture in the migration of the hydroxyapatite graft." @default.
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• W1969052017 date "1997-06-01" @default.
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• W1969052017 title "Migration of Hydroxyapatite Onlays into the Mandible and Nasal Bone and Local Bone Turnover in Growing Rabbits" @default.
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• W1969052017 doi "https://doi.org/10.1097/00006534-199706000-00024" @default.
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