Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969054503> ?p ?o ?g. }
- W1969054503 endingPage "2706" @default.
- W1969054503 startingPage "2701" @default.
- W1969054503 abstract "Membrane fusion in the secretory pathway is mediated by soluble N -ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins. Different fusion steps are thought to be effected by independent sets of SNAREs, but it is unclear whether specificity is determined by an intrinsic specificity of SNARE pairing or by upstream factors. Using a newly developed microscopy-based assay, we have investigated the SNARE specificity of homotypic early endosomal fusion. We show that early endosomes contain multiple sets of SNAREs, including, in addition to the putative early endosomal SNAREs, those involved in exocytosis and in fusion of late endosomes. We demonstrate that fusion is largely mediated by a complex formed by syntaxin 13, syntaxin 6, vti1a, and VAMP4, whereas the exocytic and late endosomal SNAREs play little or no role in the reaction. In contrast, proteoliposomes reconstituted with early endosomal SNAREs promiscuously fuse with liposomes containing exocytotic or late endosomal SNAREs. We conclude that the specificity of SNARE pairing does not suffice to determine the specificity of organelle fusion." @default.
- W1969054503 created "2016-06-24" @default.
- W1969054503 creator A5034531020 @default.
- W1969054503 creator A5037018053 @default.
- W1969054503 creator A5061167925 @default.
- W1969054503 creator A5067044886 @default.
- W1969054503 creator A5077214003 @default.
- W1969054503 creator A5078490490 @default.
- W1969054503 date "2006-02-09" @default.
- W1969054503 modified "2023-09-23" @default.
- W1969054503 title "Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity" @default.
- W1969054503 cites W1495603032 @default.
- W1969054503 cites W1538471627 @default.
- W1969054503 cites W1570678799 @default.
- W1969054503 cites W1595083713 @default.
- W1969054503 cites W1595436183 @default.
- W1969054503 cites W1822252127 @default.
- W1969054503 cites W185955435 @default.
- W1969054503 cites W1965637370 @default.
- W1969054503 cites W1971016259 @default.
- W1969054503 cites W1976540095 @default.
- W1969054503 cites W1978833026 @default.
- W1969054503 cites W1993104529 @default.
- W1969054503 cites W1996649587 @default.
- W1969054503 cites W1997278714 @default.
- W1969054503 cites W2003481405 @default.
- W1969054503 cites W2005574904 @default.
- W1969054503 cites W2013561554 @default.
- W1969054503 cites W2014045979 @default.
- W1969054503 cites W2018289835 @default.
- W1969054503 cites W2022977995 @default.
- W1969054503 cites W2027775552 @default.
- W1969054503 cites W2030972230 @default.
- W1969054503 cites W2040866860 @default.
- W1969054503 cites W2042212641 @default.
- W1969054503 cites W2047808133 @default.
- W1969054503 cites W2049550397 @default.
- W1969054503 cites W2052394407 @default.
- W1969054503 cites W2052999464 @default.
- W1969054503 cites W2055606345 @default.
- W1969054503 cites W2066444607 @default.
- W1969054503 cites W2072544389 @default.
- W1969054503 cites W2076636373 @default.
- W1969054503 cites W2082851502 @default.
- W1969054503 cites W2087585176 @default.
- W1969054503 cites W2093465143 @default.
- W1969054503 cites W2095474817 @default.
- W1969054503 cites W2100837269 @default.
- W1969054503 cites W2114277918 @default.
- W1969054503 cites W2117181594 @default.
- W1969054503 cites W2126162952 @default.
- W1969054503 cites W2127611110 @default.
- W1969054503 cites W2128635872 @default.
- W1969054503 cites W2129349918 @default.
- W1969054503 cites W2130785214 @default.
- W1969054503 cites W2135628573 @default.
- W1969054503 cites W2137163623 @default.
- W1969054503 cites W2137635572 @default.
- W1969054503 cites W2138727954 @default.
- W1969054503 cites W2144892927 @default.
- W1969054503 cites W2154100802 @default.
- W1969054503 cites W2168979413 @default.
- W1969054503 cites W2170437356 @default.
- W1969054503 cites W2178812731 @default.
- W1969054503 cites W2399280246 @default.
- W1969054503 cites W4210958643 @default.
- W1969054503 cites W4211214945 @default.
- W1969054503 cites W4293247451 @default.
- W1969054503 cites W4300569677 @default.
- W1969054503 cites W4321429492 @default.
- W1969054503 doi "https://doi.org/10.1073/pnas.0511138103" @default.
- W1969054503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1413832" @default.
- W1969054503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16469845" @default.
- W1969054503 hasPublicationYear "2006" @default.
- W1969054503 type Work @default.
- W1969054503 sameAs 1969054503 @default.
- W1969054503 citedByCount "129" @default.
- W1969054503 countsByYear W19690545032012 @default.
- W1969054503 countsByYear W19690545032013 @default.
- W1969054503 countsByYear W19690545032014 @default.
- W1969054503 countsByYear W19690545032015 @default.
- W1969054503 countsByYear W19690545032016 @default.
- W1969054503 countsByYear W19690545032017 @default.
- W1969054503 countsByYear W19690545032018 @default.
- W1969054503 countsByYear W19690545032019 @default.
- W1969054503 countsByYear W19690545032020 @default.
- W1969054503 countsByYear W19690545032021 @default.
- W1969054503 countsByYear W19690545032022 @default.
- W1969054503 countsByYear W19690545032023 @default.
- W1969054503 crossrefType "journal-article" @default.
- W1969054503 hasAuthorship W1969054503A5034531020 @default.
- W1969054503 hasAuthorship W1969054503A5037018053 @default.
- W1969054503 hasAuthorship W1969054503A5061167925 @default.
- W1969054503 hasAuthorship W1969054503A5067044886 @default.
- W1969054503 hasAuthorship W1969054503A5077214003 @default.
- W1969054503 hasAuthorship W1969054503A5078490490 @default.
- W1969054503 hasBestOaLocation W19690545032 @default.
- W1969054503 hasConcept C102747710 @default.