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- W1969057222 abstract "Lymphocytes, especially thymocytes, are highly radiosensitive and undergo “interphase death” shortly after low-dose irradiation. In this study, reagents that inhibit Ca2+-dependent signals were found to reduce radiationinduced interphase death in mouse thymocytes. Thymocytes irradiated in vitro were incubated for appropriate time periods with a calcium (Ca) chelator, Ca channel blockers, protein kinase C (PKC) inhibitors, or calmodulin (CaM) inhibitors. Cell viability was then measured by trypan blue dye exclusion. Data obtained by chelation of Ca2+ with EGTA indicated that interphase death was a Ca2+-dependent process and that Ca2+ was required in both the early and late stages of the process. Interphase death was strongly suppressed by the addition of Co2+ and La3+ ions which inhibit both receptor-operated and voltage-gated Ca channels, but not by the addition of specific voltage-gated Ca channel blockers. This suggests that Ca2+ might enter through receptor-operated Ca channels into irradiated cells. Involvement of PKC in inducing interphase death was supported by the results of experiments with PKC inhibitors such as H-7 and staurosporin. Calmodulin appeared to be uninvolved in inducing cell death. These results suggest that the induction of radiation-induced interphase death requires Ca2+, and that depletion of Ca2+ or disturbance of the Ca2+-dependent signal can reduce interphase death." @default.
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- W1969057222 date "1991-01-01" @default.
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- W1969057222 title "Reduction in Radiation-induced Interphase Death of Mouse Thymocytes by Agents that Inhibit Calcium-dependent Signals in Cells" @default.
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- W1969057222 doi "https://doi.org/10.15369/sujms1989.3.105" @default.
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