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- W1969060147 abstract "Phytolaccoside B (1), an antifungal monodesmoside triterpenoid glycoside isolated from berries of Phytolacca tetramera Hauman (Phytolaccaceae), alters the morphology of yeasts and molds. The malformations were similar to those produced by enfumafungin, a known inhibitor of (1→3)-β-d-glucan synthase, an enzyme that catalyzes the synthesis of (1→3)-β-d-glucan, one of the major polymers of the fungal cell wall. However, enzymatic assays revealed that 1 did not inhibit (1→3)-β-d-glucan synthase, but it did produce a notable enhancement of the chitin synthase 1 activity and, concomitantly, a rise in chitin, another important polymer of the fungal cell walls. This finding was corroborated by fluorescence microscopy and also by quantification of the chitin. In addition, a 2-fold increase in the thickness of the fungal cell wall was observed with transmission electronic microscopy. On the other hand, 1 neither bound to ergosterol nor caused hemolysis of red blood cells, although some fungal membrane damage was observed at the MIC of 1." @default.
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- W1969060147 date "2008-09-25" @default.
- W1969060147 modified "2023-10-02" @default.
- W1969060147 title "Evidence for the Mechanism of Action of the Antifungal Phytolaccoside B Isolated from <i>Phytolacca tetramera</i> Hauman" @default.
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- W1969060147 doi "https://doi.org/10.1021/np070660i" @default.
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