FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969064295> ?p ?o ?g. }

• W1969064295 endingPage "110" @default.
• W1969064295 startingPage "106" @default.
• W1969064295 abstract "Transcriptomic analyses revealed a discriminating gene expression profile in human CD34+ progenitor-derived dendritic cells (DC) after exposure to skin sensitizers versus non-sensitizers. Starting from the differential expression in a small set of genes, a preliminary classification model (VITOSENS®) has been developed to identify chemicals as (non-)sensitizing. The objective of the current study is to gain knowledge on the role of the VITOSENS® markers in the DC maturation process, as well as to investigate their activation by a skin sensitizer versus a non-sensitizing danger molecule. To evaluate the functional relevance of VITOSENS® biomarkers in DC maturation, their response induced by the sensitizer dinitrofluorobenzene (DNFB) was pharmacologically counteracted. Flow cytometry analyses revealed that CD86 was down-regulated after COX2 inhibition, whereas expression of HLA-DR was reduced by stimulating CCR2. When exposing DC to DNFB versus lipopolysaccharide S (LPS), expression of most discriminating genes CREM and CCR2 was not altered by LPS as opposed to DNFB. To summarize, the observations in this research indicate that a selection of the VITOSENS® genes may be functionally involved in sensitizer-induced DC activation. By comparing their responsiveness towards a non-sensitizing danger signal and a sensitizer, VITOSENS® gene markers CREM and CCR2 appear to display a specific response." @default.
• W1969064295 created "2016-06-24" @default.
• W1969064295 creator A5013258216 @default.
• W1969064295 creator A5019338245 @default.
• W1969064295 creator A5037454723 @default.
• W1969064295 creator A5053729120 @default.
• W1969064295 creator A5058883955 @default.
• W1969064295 creator A5085098410 @default.
• W1969064295 creator A5089955088 @default.
• W1969064295 date "2011-06-01" @default.
• W1969064295 modified "2023-10-17" @default.
• W1969064295 title "Functionality and specificity of gene markers for skin sensitization in dendritic cells" @default.
• W1969064295 cites W1251710288 @default.
• W1969064295 cites W1577577364 @default.
• W1969064295 cites W1769928764 @default.
• W1969064295 cites W1967977080 @default.
• W1969064295 cites W1972886995 @default.
• W1969064295 cites W1981932944 @default.
• W1969064295 cites W1985219178 @default.
• W1969064295 cites W1989552966 @default.
• W1969064295 cites W2018050026 @default.
• W1969064295 cites W2044357203 @default.
• W1969064295 cites W2044412725 @default.
• W1969064295 cites W2049636219 @default.
• W1969064295 cites W2066718029 @default.
• W1969064295 cites W2071953074 @default.
• W1969064295 cites W2083141377 @default.
• W1969064295 cites W2088956853 @default.
• W1969064295 cites W2096301496 @default.
• W1969064295 cites W2098635583 @default.
• W1969064295 cites W2108251490 @default.
• W1969064295 cites W2120930368 @default.
• W1969064295 cites W2138581811 @default.
• W1969064295 cites W2141286193 @default.
• W1969064295 cites W2145736817 @default.
• W1969064295 cites W2171005142 @default.
• W1969064295 cites W97158386 @default.
• W1969064295 doi "https://doi.org/10.1016/j.toxlet.2011.02.015" @default.
• W1969064295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21362464" @default.
• W1969064295 hasPublicationYear "2011" @default.
• W1969064295 type Work @default.
• W1969064295 sameAs 1969064295 @default.
• W1969064295 citedByCount "22" @default.
• W1969064295 countsByYear W19690642952012 @default.
• W1969064295 countsByYear W19690642952013 @default.
• W1969064295 countsByYear W19690642952014 @default.
• W1969064295 countsByYear W19690642952015 @default.
• W1969064295 countsByYear W19690642952016 @default.
• W1969064295 countsByYear W19690642952017 @default.
• W1969064295 countsByYear W19690642952019 @default.
• W1969064295 countsByYear W19690642952020 @default.
• W1969064295 countsByYear W19690642952023 @default.
• W1969064295 crossrefType "journal-article" @default.
• W1969064295 hasAuthorship W1969064295A5013258216 @default.
• W1969064295 hasAuthorship W1969064295A5019338245 @default.
• W1969064295 hasAuthorship W1969064295A5037454723 @default.
• W1969064295 hasAuthorship W1969064295A5053729120 @default.
• W1969064295 hasAuthorship W1969064295A5058883955 @default.
• W1969064295 hasAuthorship W1969064295A5085098410 @default.
• W1969064295 hasAuthorship W1969064295A5089955088 @default.
• W1969064295 hasConcept C104317684 @default.
• W1969064295 hasConcept C127716648 @default.
• W1969064295 hasConcept C12823836 @default.
• W1969064295 hasConcept C13373296 @default.
• W1969064295 hasConcept C147483822 @default.
• W1969064295 hasConcept C150194340 @default.
• W1969064295 hasConcept C162317418 @default.
• W1969064295 hasConcept C169760540 @default.
• W1969064295 hasConcept C203014093 @default.
• W1969064295 hasConcept C206615009 @default.
• W1969064295 hasConcept C24998067 @default.
• W1969064295 hasConcept C2776217527 @default.
• W1969064295 hasConcept C2778170410 @default.
• W1969064295 hasConcept C2778754761 @default.
• W1969064295 hasConcept C2781101188 @default.
• W1969064295 hasConcept C54355233 @default.
• W1969064295 hasConcept C553184892 @default.
• W1969064295 hasConcept C86803240 @default.
• W1969064295 hasConcept C8891405 @default.
• W1969064295 hasConcept C95444343 @default.
• W1969064295 hasConceptScore W1969064295C104317684 @default.
• W1969064295 hasConceptScore W1969064295C127716648 @default.
• W1969064295 hasConceptScore W1969064295C12823836 @default.
• W1969064295 hasConceptScore W1969064295C13373296 @default.
• W1969064295 hasConceptScore W1969064295C147483822 @default.
• W1969064295 hasConceptScore W1969064295C150194340 @default.
• W1969064295 hasConceptScore W1969064295C162317418 @default.
• W1969064295 hasConceptScore W1969064295C169760540 @default.
• W1969064295 hasConceptScore W1969064295C203014093 @default.
• W1969064295 hasConceptScore W1969064295C206615009 @default.
• W1969064295 hasConceptScore W1969064295C24998067 @default.
• W1969064295 hasConceptScore W1969064295C2776217527 @default.
• W1969064295 hasConceptScore W1969064295C2778170410 @default.
• W1969064295 hasConceptScore W1969064295C2778754761 @default.
• W1969064295 hasConceptScore W1969064295C2781101188 @default.
• W1969064295 hasConceptScore W1969064295C54355233 @default.
• W1969064295 hasConceptScore W1969064295C553184892 @default.
• W1969064295 hasConceptScore W1969064295C86803240 @default.

• next