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- W1969065997 abstract "Small-scale, high-precision liquid delivery technologies are a welcome innovation in a number of areas. For example, the increasing miniaturization of microarrays for use in genomics and proteomics makes impractical conventional dispensing systems based on pipettes, pin and ring arrangements, and inkjet printing. Microfabricated probes developed for scanning probe microscopy (SPM), on the other hand, represent unique, versatile tools for working at the nanometer scale. Several techniques exist for liquid dispensing based on SPMlike nanoprobes. The first of these, dip-pen nanolithography (DPN), is based on immersing an SPM probe into molecular solution (the ‘ink’), and then writing molecular patterns with feature sizes as small as several tens of nanometers. An alternative is bioplume technology, which allows larger amounts of ink to be deposited by charging the probe with ink along the probe shaft. Surface structures created in this way, however, have larger dimensions. Here we describe a technology called nanoscale dispensing (NADIS) that is based on apertured nanoprobes. 4 Hollow probes are loaded with ink,either manually or usinga fluidicchannelsystem. When the probe tip makes contact with the substrate, a small amount of liquid is transferredthrough theaperture to the surface: see Figure 1 (left).Tocontrol the deposition process, the surface energies of both probe and substrate must be sufficiently controlled. Figure 1 (right and inset) shows a scanning electron micrograph of a NADIS probe with an integrated channel system. This allows liquid delivery from distant macroscopic reservoirs, thus opening the way to high-volume deposition applications without having to repeatedly reload the probe. Similar developments have been reported for DPN-like systems. Figure 1. (Left) In nanoscale dispensing (NADIS), liquid is deposited by an apertured probe on contact with a substrate surface. (Right) Scanning electron microscope image of a NADIS probe with a nanochannel incorporated into the cantilever. (Inset) Cross-section of a cantilever beam shows the hollow channel structure." @default.
- W1969065997 created "2016-06-24" @default.
- W1969065997 creator A5060811924 @default.
- W1969065997 date "2006-01-01" @default.
- W1969065997 modified "2023-10-16" @default.
- W1969065997 title "Liquid dispensing of ultrasmall volumes using miniaturized probes" @default.
- W1969065997 cites W1976806346 @default.
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- W1969065997 doi "https://doi.org/10.1117/2.1200611.0478" @default.
- W1969065997 hasPublicationYear "2006" @default.
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