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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969066423> ?p ?o ?g. }

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• W1969066423 startingPage "841" @default.
• W1969066423 abstract "We studied the activity of a single oral dose of RWJ-67657, a synthetic p38 mitogen-activated protein kinase inhibitor, in preventing dual leukocyte/endothelial activation after endotoxin infusion in healthy volunteers.Prospective placebo-controlled study.Intensive care unit at a university medical center.Twenty-one healthy male volunteers.Endotoxin (4 ng/kg) as a 1-min infusion. According to randomization, the volunteers received placebo (n = 6) or 1400 mg (n = 4), 700 mg (n = 6), or 350 mg (n = 5) of RWJ-67657.Neutrophil activation was investigated by analyzing the extent of membrane expression of adhesion markers by calibrated flow cytometry. Circulating intercellular adhesion molecule-1 and E-selectin were measured by enzyme-linked immunosorbent assays. The endotoxin-induced shedding of L-selectin was diminished in a dose-dependent manner (p <.0001). High-dose RWJ-67657 prevented up-regulation of the integrins CD11b (p <.01) and CD 66b (p <.01) on neutrophils. The endotoxin-induced increase in circulating intercellular adhesion molecule-1 and circulation E-selectin was almost completely prevented by high-dose RWJ-67657.A single oral dose of RWJ-67657 prevented neutrophil and endothelial activation after endotoxin infusion." @default.
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• W1969066423 date "2002-04-01" @default.
• W1969066423 modified "2023-09-27" @default.
• W1969066423 title "Inhibition of p38 mitogen-activated protein kinase: Dose-dependent suppression of leukocyte and endothelial response after endotoxin challenge in humans*" @default.
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• W1969066423 doi "https://doi.org/10.1097/00003246-200204000-00021" @default.
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