FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969071781> ?p ?o ?g. }

• W1969071781 endingPage "1347" @default.
• W1969071781 startingPage "1340" @default.
• W1969071781 abstract "Extracellular matrix (ECM) degradation is performed primarily by matrix metalloproteinases (MMPs). MMPs have recently been shown to regulate synaptic activity in the hippocampus and to affect memory and learning. The tissue inhibitor of metalloproteinase (Timp) is an endogenous factor that controls MMP activity by binding to the catalytic site of MMPs. At present, four Timp isotypes have been reported (Timp-1 through Timp-4) with 35–50% amino-acid sequence homology. Timp-3 is a unique member of Timp proteins in that it is bound to the ECM. In this study, we used the passive avoidance test, active avoidance test, and water maze test to examine the cognitive function in Timp-3 knockout (KO) mice. Habituation was evaluated using the open-field test. The water maze test showed that Timp-3 KO mice exhibit deterioration in cognitive function compared with wild-type (WT) mice. The open-field test showed decreased habituation of Timp-3 KO mice. Immunostaining of brain slices revealed the expression of Timp-3 in the hippocampus. In situ zymography of the hippocampus showed increased gelatinolytic activity in Timp-3 KO mice compared with WT mice. These results present the first evidence of Timp-3 involvement in cognitive function and hippocampal MMP activity in mice. Moreover, our findings suggest a novel therapeutic target to be explored for improvement of cognitive function in humans." @default.
• W1969071781 created "2016-06-24" @default.
• W1969071781 creator A5001563356 @default.
• W1969071781 creator A5011935809 @default.
• W1969071781 creator A5012868995 @default.
• W1969071781 creator A5021267745 @default.
• W1969071781 creator A5030786170 @default.
• W1969071781 creator A5043576411 @default.
• W1969071781 creator A5058377311 @default.
• W1969071781 creator A5060467145 @default.
• W1969071781 creator A5082949432 @default.
• W1969071781 creator A5084736532 @default.
• W1969071781 creator A5087210984 @default.
• W1969071781 creator A5091708188 @default.
• W1969071781 date "2009-12-01" @default.
• W1969071781 modified "2023-09-30" @default.
• W1969071781 title "Timp-3 deficiency impairs cognitive function in mice" @default.
• W1969071781 cites W1491678226 @default.
• W1969071781 cites W1555498151 @default.
• W1969071781 cites W1594229796 @default.
• W1969071781 cites W1602981281 @default.
• W1969071781 cites W1965515526 @default.
• W1969071781 cites W1965533650 @default.
• W1969071781 cites W1965831612 @default.
• W1969071781 cites W1979841422 @default.
• W1969071781 cites W1986831590 @default.
• W1969071781 cites W1997380254 @default.
• W1969071781 cites W2002771508 @default.
• W1969071781 cites W2003554016 @default.
• W1969071781 cites W2011531352 @default.
• W1969071781 cites W2015242919 @default.
• W1969071781 cites W2036792388 @default.
• W1969071781 cites W2041216210 @default.
• W1969071781 cites W2045263244 @default.
• W1969071781 cites W2046329404 @default.
• W1969071781 cites W2052268015 @default.
• W1969071781 cites W2055030770 @default.
• W1969071781 cites W2055535173 @default.
• W1969071781 cites W2058859626 @default.
• W1969071781 cites W2074438676 @default.
• W1969071781 cites W2078282082 @default.
• W1969071781 cites W2079241115 @default.
• W1969071781 cites W2091773205 @default.
• W1969071781 cites W2102146294 @default.
• W1969071781 cites W2105028929 @default.
• W1969071781 cites W2107726585 @default.
• W1969071781 cites W2107984202 @default.
• W1969071781 cites W2135585199 @default.
• W1969071781 cites W2136404679 @default.
• W1969071781 cites W2148001793 @default.
• W1969071781 cites W2153321407 @default.
• W1969071781 cites W2154166490 @default.
• W1969071781 cites W2156513567 @default.
• W1969071781 cites W2170045306 @default.
• W1969071781 cites W3118906554 @default.
• W1969071781 cites W4237589349 @default.
• W1969071781 cites W4250908540 @default.
• W1969071781 cites W4256533826 @default.
• W1969071781 doi "https://doi.org/10.1038/labinvest.2009.101" @default.
• W1969071781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3047444" @default.
• W1969071781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19806081" @default.
• W1969071781 hasPublicationYear "2009" @default.
• W1969071781 type Work @default.
• W1969071781 sameAs 1969071781 @default.
• W1969071781 citedByCount "18" @default.
• W1969071781 countsByYear W19690717812012 @default.
• W1969071781 countsByYear W19690717812014 @default.
• W1969071781 countsByYear W19690717812019 @default.
• W1969071781 countsByYear W19690717812020 @default.
• W1969071781 countsByYear W19690717812021 @default.
• W1969071781 countsByYear W19690717812022 @default.
• W1969071781 countsByYear W19690717812023 @default.
• W1969071781 crossrefType "journal-article" @default.
• W1969071781 hasAuthorship W1969071781A5001563356 @default.
• W1969071781 hasAuthorship W1969071781A5011935809 @default.
• W1969071781 hasAuthorship W1969071781A5012868995 @default.
• W1969071781 hasAuthorship W1969071781A5021267745 @default.
• W1969071781 hasAuthorship W1969071781A5030786170 @default.
• W1969071781 hasAuthorship W1969071781A5043576411 @default.
• W1969071781 hasAuthorship W1969071781A5058377311 @default.
• W1969071781 hasAuthorship W1969071781A5060467145 @default.
• W1969071781 hasAuthorship W1969071781A5082949432 @default.
• W1969071781 hasAuthorship W1969071781A5084736532 @default.
• W1969071781 hasAuthorship W1969071781A5087210984 @default.
• W1969071781 hasAuthorship W1969071781A5091708188 @default.
• W1969071781 hasBestOaLocation W19690717811 @default.
• W1969071781 hasConcept C109523444 @default.
• W1969071781 hasConcept C126322002 @default.
• W1969071781 hasConcept C134018914 @default.
• W1969071781 hasConcept C148762608 @default.
• W1969071781 hasConcept C15744967 @default.
• W1969071781 hasConcept C169760540 @default.
• W1969071781 hasConcept C170493617 @default.
• W1969071781 hasConcept C182704531 @default.
• W1969071781 hasConcept C185592680 @default.
• W1969071781 hasConcept C204232928 @default.
• W1969071781 hasConcept C2779085643 @default.
• W1969071781 hasConcept C2781161787 @default.

• next