FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969072247> ?p ?o ?g. }

• W1969072247 endingPage "1529" @default.
• W1969072247 startingPage "1526" @default.
• W1969072247 abstract "Double-stranded ribonucleic acid (dsRNA) serves as a danger signal associated with viral infection and leads to stimulation of innate immune cells. In contrast, the immunostimulatory potential of single-stranded RNA (ssRNA) is poorly understood and innate immune receptors for ssRNA are unknown. We report that guanosine (G)- and uridine (U)-rich ssRNA oligonucleotides derived from human immunodeficiency virus-1 (HIV-1) stimulate dendritic cells (DC) and macrophages to secrete interferon-alpha and proinflammatory, as well as regulatory, cytokines. By using Toll-like receptor (TLR)-deficient mice and genetic complementation, we show that murine TLR7 and human TLR8 mediate species-specific recognition of GU-rich ssRNA. These data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8." @default.
• W1969072247 created "2016-06-24" @default.
• W1969072247 creator A5004324970 @default.
• W1969072247 creator A5010882504 @default.
• W1969072247 creator A5018553332 @default.
• W1969072247 creator A5020476787 @default.
• W1969072247 creator A5029854341 @default.
• W1969072247 creator A5041321400 @default.
• W1969072247 creator A5046981639 @default.
• W1969072247 creator A5052605913 @default.
• W1969072247 creator A5083708821 @default.
• W1969072247 date "2004-03-05" @default.
• W1969072247 modified "2023-10-18" @default.
• W1969072247 title "Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8" @default.
• W1969072247 cites W1514540900 @default.
• W1969072247 cites W1547938117 @default.
• W1969072247 cites W1972776583 @default.
• W1969072247 cites W1978962348 @default.
• W1969072247 cites W1991236592 @default.
• W1969072247 cites W2003253889 @default.
• W1969072247 cites W2004726009 @default.
• W1969072247 cites W2013771819 @default.
• W1969072247 cites W2025412364 @default.
• W1969072247 cites W2034708798 @default.
• W1969072247 cites W2069981713 @default.
• W1969072247 cites W2076361525 @default.
• W1969072247 cites W2101363646 @default.
• W1969072247 cites W2113779347 @default.
• W1969072247 cites W2116692899 @default.
• W1969072247 cites W2128117338 @default.
• W1969072247 cites W2130834121 @default.
• W1969072247 cites W2148178789 @default.
• W1969072247 cites W2166026289 @default.
• W1969072247 cites W2167614869 @default.
• W1969072247 cites W2170240282 @default.
• W1969072247 doi "https://doi.org/10.1126/science.1093620" @default.
• W1969072247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14976262" @default.
• W1969072247 hasPublicationYear "2004" @default.
• W1969072247 type Work @default.
• W1969072247 sameAs 1969072247 @default.
• W1969072247 citedByCount "3442" @default.
• W1969072247 countsByYear W19690722472012 @default.
• W1969072247 countsByYear W19690722472013 @default.
• W1969072247 countsByYear W19690722472014 @default.
• W1969072247 countsByYear W19690722472015 @default.
• W1969072247 countsByYear W19690722472016 @default.
• W1969072247 countsByYear W19690722472017 @default.
• W1969072247 countsByYear W19690722472018 @default.
• W1969072247 countsByYear W19690722472019 @default.
• W1969072247 countsByYear W19690722472020 @default.
• W1969072247 countsByYear W19690722472021 @default.
• W1969072247 countsByYear W19690722472022 @default.
• W1969072247 countsByYear W19690722472023 @default.
• W1969072247 crossrefType "journal-article" @default.
• W1969072247 hasAuthorship W1969072247A5004324970 @default.
• W1969072247 hasAuthorship W1969072247A5010882504 @default.
• W1969072247 hasAuthorship W1969072247A5018553332 @default.
• W1969072247 hasAuthorship W1969072247A5020476787 @default.
• W1969072247 hasAuthorship W1969072247A5029854341 @default.
• W1969072247 hasAuthorship W1969072247A5041321400 @default.
• W1969072247 hasAuthorship W1969072247A5046981639 @default.
• W1969072247 hasAuthorship W1969072247A5052605913 @default.
• W1969072247 hasAuthorship W1969072247A5083708821 @default.
• W1969072247 hasBestOaLocation W19690722471 @default.
• W1969072247 hasConcept C104317684 @default.
• W1969072247 hasConcept C111289621 @default.
• W1969072247 hasConcept C134474686 @default.
• W1969072247 hasConcept C136449434 @default.
• W1969072247 hasConcept C150194340 @default.
• W1969072247 hasConcept C159047783 @default.
• W1969072247 hasConcept C164027704 @default.
• W1969072247 hasConcept C166703698 @default.
• W1969072247 hasConcept C170493617 @default.
• W1969072247 hasConcept C190727270 @default.
• W1969072247 hasConcept C203014093 @default.
• W1969072247 hasConcept C2191507 @default.
• W1969072247 hasConcept C2776178377 @default.
• W1969072247 hasConcept C2776709828 @default.
• W1969072247 hasConcept C2776914184 @default.
• W1969072247 hasConcept C2776954689 @default.
• W1969072247 hasConcept C2778420691 @default.
• W1969072247 hasConcept C2779138994 @default.
• W1969072247 hasConcept C2779836521 @default.
• W1969072247 hasConcept C55493867 @default.
• W1969072247 hasConcept C67705224 @default.
• W1969072247 hasConcept C86803240 @default.
• W1969072247 hasConcept C8891405 @default.
• W1969072247 hasConcept C95444343 @default.
• W1969072247 hasConceptScore W1969072247C104317684 @default.
• W1969072247 hasConceptScore W1969072247C111289621 @default.
• W1969072247 hasConceptScore W1969072247C134474686 @default.
• W1969072247 hasConceptScore W1969072247C136449434 @default.
• W1969072247 hasConceptScore W1969072247C150194340 @default.
• W1969072247 hasConceptScore W1969072247C159047783 @default.
• W1969072247 hasConceptScore W1969072247C164027704 @default.
• W1969072247 hasConceptScore W1969072247C166703698 @default.
• W1969072247 hasConceptScore W1969072247C170493617 @default.
• W1969072247 hasConceptScore W1969072247C190727270 @default.

• next