FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969074434> ?p ?o ?g. }

• W1969074434 endingPage "141" @default.
• W1969074434 startingPage "132" @default.
• W1969074434 abstract "Ultra-low doses of opioid receptor antagonists inhibit development of chronic spinal morphine tolerance. As this phenomenon mechanistically resembles acute tolerance, the present study examined actions of opioid receptor antagonists on acute spinal morphine tolerance. In adult rats, administration of three intrathecal injections of morphine (15 microg) at 90 min intervals produced a significant decline of the antinociceptive effect and loss of agonist potency in both the tail-flick and paw-pressure tests. These reduced responses, indicative of acute tolerance, were blocked by co-injection of morphine (15 microg) with naltrexone (NTX, 0.05 ng), D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTAP, 0.001 ng), naltrindole (0.06 ng), or nor-binaltorphimine (0.1 ng). Repeated injections of CTAP, naltrindole, or nor-binaltorphimine without morphine elicited a delayed weak antinociceptive response which was blocked by a high dose of naltrexone (2 microg). In another set of experiments, administration of low dose spinal (0.05 ng) or systemic (0.01 microg/kg) morphine produced a sustained thermal hyperalgesia. This response was blocked by opioid receptor antagonists at doses inhibiting development of acute morphine tolerance. Lastly, an acute spinal injection of morphine (15 microg) with naltrexone (0.05 ng) produced a sustained analgesic response; this was antagonized by adenosine receptor antagonist, 8-phenyltheophylline (3 microg). The results show that ultra-low doses of opioid receptor antagonists block acute tolerance to morphine. This effect may result from blockade of opioid excitatory effects that produce a latent hyperalgesia that then contributes to induction of tolerance. The sustained antinociception produced by combination of morphine with an opioid receptor antagonist shows dependency on the adenosine receptor activity." @default.
• W1969074434 created "2016-06-24" @default.
• W1969074434 creator A5016606343 @default.
• W1969074434 creator A5026003069 @default.
• W1969074434 creator A5059794403 @default.
• W1969074434 creator A5074399476 @default.
• W1969074434 date "2007-04-01" @default.
• W1969074434 modified "2023-10-17" @default.
• W1969074434 title "Inhibition of tolerance to spinal morphine antinociception by low doses of opioid receptor antagonists" @default.
• W1969074434 cites W1531160152 @default.
• W1969074434 cites W1646324094 @default.
• W1969074434 cites W1852077611 @default.
• W1969074434 cites W1970417151 @default.
• W1969074434 cites W1971518626 @default.
• W1969074434 cites W1982184237 @default.
• W1969074434 cites W1997179101 @default.
• W1969074434 cites W2001131419 @default.
• W1969074434 cites W2007174401 @default.
• W1969074434 cites W2007659283 @default.
• W1969074434 cites W2014435395 @default.
• W1969074434 cites W2014849167 @default.
• W1969074434 cites W2019867656 @default.
• W1969074434 cites W2021793024 @default.
• W1969074434 cites W2029812913 @default.
• W1969074434 cites W2030383594 @default.
• W1969074434 cites W2040725197 @default.
• W1969074434 cites W2043738056 @default.
• W1969074434 cites W2057711636 @default.
• W1969074434 cites W2062714491 @default.
• W1969074434 cites W2063757984 @default.
• W1969074434 cites W2072203697 @default.
• W1969074434 cites W2088213907 @default.
• W1969074434 cites W2096686163 @default.
• W1969074434 cites W2102262969 @default.
• W1969074434 cites W2103780725 @default.
• W1969074434 cites W2142899898 @default.
• W1969074434 cites W2143046795 @default.
• W1969074434 cites W2146166752 @default.
• W1969074434 cites W2147107991 @default.
• W1969074434 cites W2164039705 @default.
• W1969074434 cites W4249060234 @default.
• W1969074434 cites W4297627420 @default.
• W1969074434 doi "https://doi.org/10.1016/j.ejphar.2006.12.013" @default.
• W1969074434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17307158" @default.
• W1969074434 hasPublicationYear "2007" @default.
• W1969074434 type Work @default.
• W1969074434 sameAs 1969074434 @default.
• W1969074434 citedByCount "32" @default.
• W1969074434 countsByYear W19690744342012 @default.
• W1969074434 countsByYear W19690744342013 @default.
• W1969074434 countsByYear W19690744342014 @default.
• W1969074434 countsByYear W19690744342015 @default.
• W1969074434 countsByYear W19690744342016 @default.
• W1969074434 countsByYear W19690744342017 @default.
• W1969074434 countsByYear W19690744342018 @default.
• W1969074434 countsByYear W19690744342021 @default.
• W1969074434 countsByYear W19690744342022 @default.
• W1969074434 crossrefType "journal-article" @default.
• W1969074434 hasAuthorship W1969074434A5016606343 @default.
• W1969074434 hasAuthorship W1969074434A5026003069 @default.
• W1969074434 hasAuthorship W1969074434A5059794403 @default.
• W1969074434 hasAuthorship W1969074434A5074399476 @default.
• W1969074434 hasConcept C126322002 @default.
• W1969074434 hasConcept C134018914 @default.
• W1969074434 hasConcept C15490471 @default.
• W1969074434 hasConcept C170493617 @default.
• W1969074434 hasConcept C185592680 @default.
• W1969074434 hasConcept C2777389121 @default.
• W1969074434 hasConcept C2777953665 @default.
• W1969074434 hasConcept C2777972943 @default.
• W1969074434 hasConcept C2778938600 @default.
• W1969074434 hasConcept C2779245659 @default.
• W1969074434 hasConcept C2779886867 @default.
• W1969074434 hasConcept C2779985140 @default.
• W1969074434 hasConcept C2780820201 @default.
• W1969074434 hasConcept C2781063702 @default.
• W1969074434 hasConcept C71924100 @default.
• W1969074434 hasConcept C946728 @default.
• W1969074434 hasConcept C98274493 @default.
• W1969074434 hasConceptScore W1969074434C126322002 @default.
• W1969074434 hasConceptScore W1969074434C134018914 @default.
• W1969074434 hasConceptScore W1969074434C15490471 @default.
• W1969074434 hasConceptScore W1969074434C170493617 @default.
• W1969074434 hasConceptScore W1969074434C185592680 @default.
• W1969074434 hasConceptScore W1969074434C2777389121 @default.
• W1969074434 hasConceptScore W1969074434C2777953665 @default.
• W1969074434 hasConceptScore W1969074434C2777972943 @default.
• W1969074434 hasConceptScore W1969074434C2778938600 @default.
• W1969074434 hasConceptScore W1969074434C2779245659 @default.
• W1969074434 hasConceptScore W1969074434C2779886867 @default.
• W1969074434 hasConceptScore W1969074434C2779985140 @default.
• W1969074434 hasConceptScore W1969074434C2780820201 @default.
• W1969074434 hasConceptScore W1969074434C2781063702 @default.
• W1969074434 hasConceptScore W1969074434C71924100 @default.
• W1969074434 hasConceptScore W1969074434C946728 @default.
• W1969074434 hasConceptScore W1969074434C98274493 @default.
• W1969074434 hasIssue "2-3" @default.
• W1969074434 hasLocation W19690744341 @default.

• next