Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969074927> ?p ?o ?g. }
- W1969074927 endingPage "2050" @default.
- W1969074927 startingPage "2043" @default.
- W1969074927 abstract "Glycogen synthase kinase‑3 (GSK‑3) is a pleiotropic serine/threonine protein kinase found in almost all eukaryotes. It is structurally highly conserved and has been identified as a multifaceted enzyme affecting a wide range of biological functions, including gene expression and cellular processes. There are two closely related isoforms of GSK‑3; GSK‑3α and GSK‑3β. The latter appears to play crucial roles in regulating the pathogenesis of diverse diseases, including neurodegenerative disease. The present review focuses on the involvement of this protein in Parkinson's disease (PD), a common neurodegenerative disorder characterized by the gradually progressive and selective loss of dopaminergic neurons, and by intracellular inclusions known as Lewy bodies (LBs) expressed in surviving neurons of the substantia nigra (SN). GSK‑3β is involved in multiple signaling pathways and has several phosphorylation targets. Numerous apoptotic conditions can be facilitated by the GSK‑3β signaling pathways. Studies have shown that GSK‑3β inhibition protects the dopaminergic neurons from various stress‑induced injuries, indicating the involvement of GSK‑3β in PD pathogenesis. However, the underlying mechanisms of the protective effect of GSK‑3β inhibition on dopaminergic neurons in PD is not completely understood. Multiple pathological events have been recognized to be responsible for the loss of dopaminergic neurons in PD, including mitochondrial dysfunction, oxidative stress, protein aggregation and neuroinflammation. The present review stresses the regulatory roles of GSK‑3β in these events and in dopaminergic neuron degeneration, in an attempt to gain an improved understanding of the underlying mechanisms and to provide a potential effective therapeutic target for PD." @default.
- W1969074927 created "2016-06-24" @default.
- W1969074927 creator A5004512291 @default.
- W1969074927 creator A5007873838 @default.
- W1969074927 creator A5017541508 @default.
- W1969074927 creator A5064092993 @default.
- W1969074927 creator A5084592351 @default.
- W1969074927 date "2014-03-28" @default.
- W1969074927 modified "2023-10-14" @default.
- W1969074927 title "Association of glycogen synthase kinase-3β with Parkinson’s disease (Review)" @default.
- W1969074927 cites W116302275 @default.
- W1969074927 cites W1504584187 @default.
- W1969074927 cites W1516639618 @default.
- W1969074927 cites W1524417563 @default.
- W1969074927 cites W1526569505 @default.
- W1969074927 cites W1527671059 @default.
- W1969074927 cites W1532684736 @default.
- W1969074927 cites W1554372630 @default.
- W1969074927 cites W1832700959 @default.
- W1969074927 cites W1937509739 @default.
- W1969074927 cites W1963940540 @default.
- W1969074927 cites W1964230438 @default.
- W1969074927 cites W1965624208 @default.
- W1969074927 cites W1965705558 @default.
- W1969074927 cites W1965888147 @default.
- W1969074927 cites W1967066491 @default.
- W1969074927 cites W1969800514 @default.
- W1969074927 cites W1970974990 @default.
- W1969074927 cites W1971701992 @default.
- W1969074927 cites W1975454216 @default.
- W1969074927 cites W1977098321 @default.
- W1969074927 cites W1977267085 @default.
- W1969074927 cites W1981409516 @default.
- W1969074927 cites W1981744155 @default.
- W1969074927 cites W1983055247 @default.
- W1969074927 cites W1987349521 @default.
- W1969074927 cites W1991020561 @default.
- W1969074927 cites W1993203039 @default.
- W1969074927 cites W1996010648 @default.
- W1969074927 cites W1997124326 @default.
- W1969074927 cites W1997326200 @default.
- W1969074927 cites W1998453171 @default.
- W1969074927 cites W2002506451 @default.
- W1969074927 cites W2003757791 @default.
- W1969074927 cites W2004349171 @default.
- W1969074927 cites W2005322339 @default.
- W1969074927 cites W2005853389 @default.
- W1969074927 cites W2006869862 @default.
- W1969074927 cites W2008168871 @default.
- W1969074927 cites W2008702759 @default.
- W1969074927 cites W2008748100 @default.
- W1969074927 cites W2009839264 @default.
- W1969074927 cites W2011041372 @default.
- W1969074927 cites W2011685758 @default.
- W1969074927 cites W2014210332 @default.
- W1969074927 cites W2014415555 @default.
- W1969074927 cites W2015472023 @default.
- W1969074927 cites W2016344164 @default.
- W1969074927 cites W2016442075 @default.
- W1969074927 cites W2022060333 @default.
- W1969074927 cites W2024709318 @default.
- W1969074927 cites W2025922492 @default.
- W1969074927 cites W2026849735 @default.
- W1969074927 cites W2029503022 @default.
- W1969074927 cites W2034150230 @default.
- W1969074927 cites W2034545642 @default.
- W1969074927 cites W2035808534 @default.
- W1969074927 cites W2038557175 @default.
- W1969074927 cites W2045416175 @default.
- W1969074927 cites W2046982257 @default.
- W1969074927 cites W2047677635 @default.
- W1969074927 cites W2049612563 @default.
- W1969074927 cites W2050118590 @default.
- W1969074927 cites W2053053005 @default.
- W1969074927 cites W2053692735 @default.
- W1969074927 cites W2054780831 @default.
- W1969074927 cites W2054903524 @default.
- W1969074927 cites W2057574587 @default.
- W1969074927 cites W2062618220 @default.
- W1969074927 cites W2063249182 @default.
- W1969074927 cites W2063504429 @default.
- W1969074927 cites W2064859339 @default.
- W1969074927 cites W2064913654 @default.
- W1969074927 cites W2064978332 @default.
- W1969074927 cites W2065961022 @default.
- W1969074927 cites W2072942101 @default.
- W1969074927 cites W2073264699 @default.
- W1969074927 cites W2074833985 @default.
- W1969074927 cites W2075281870 @default.
- W1969074927 cites W2076155053 @default.
- W1969074927 cites W2078716275 @default.
- W1969074927 cites W2078961126 @default.
- W1969074927 cites W2079718442 @default.
- W1969074927 cites W2082510957 @default.
- W1969074927 cites W2085291084 @default.
- W1969074927 cites W2086208850 @default.
- W1969074927 cites W2087497948 @default.
- W1969074927 cites W2088863630 @default.