Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969091108> ?p ?o ?g. }
- W1969091108 endingPage "20895" @default.
- W1969091108 startingPage "20883" @default.
- W1969091108 abstract "There is increasing evidence for the involvement of lipid membranes in both the functional and pathological properties of α-synuclein (α-Syn). Despite many investigations to characterize the binding of α-Syn to membranes, there is still a lack of understanding of the binding mode linking the properties of lipid membranes to α-Syn insertion into these dynamic structures. Using a combination of an optical biosensing technique and in situ atomic force microscopy, we show that the binding strength of α-Syn is related to the specificity of the lipid environment (the lipid chemistry and steric properties within a bilayer structure) and to the ability of the membranes to accommodate and remodel upon the interaction of α-Syn with lipid membranes. We show that this interaction results in the insertion of α-Syn into the region of the headgroups, inducing a lateral expansion of lipid molecules that can progress to further bilayer remodeling, such as membrane thinning and expansion of lipids out of the membrane plane. We provide new insights into the affinity of α-Syn for lipid packing defects found in vesicles of high curvature and in planar membranes with cone-shaped lipids and suggest a comprehensive model of the interaction between α-Syn and lipid bilayers. The ability of α-Syn to sense lipid packing defects and to remodel membrane structure supports its proposed role in vesicle trafficking." @default.
- W1969091108 created "2016-06-24" @default.
- W1969091108 creator A5018892762 @default.
- W1969091108 creator A5021024576 @default.
- W1969091108 creator A5046390320 @default.
- W1969091108 creator A5062771673 @default.
- W1969091108 creator A5072159508 @default.
- W1969091108 creator A5086082881 @default.
- W1969091108 creator A5091898546 @default.
- W1969091108 date "2013-07-01" @default.
- W1969091108 modified "2023-10-14" @default.
- W1969091108 title "α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling" @default.
- W1969091108 cites W1517181973 @default.
- W1969091108 cites W1527671059 @default.
- W1969091108 cites W1964741996 @default.
- W1969091108 cites W1966130903 @default.
- W1969091108 cites W1968077397 @default.
- W1969091108 cites W1969130034 @default.
- W1969091108 cites W1971116939 @default.
- W1969091108 cites W1971546470 @default.
- W1969091108 cites W1976081665 @default.
- W1969091108 cites W1976445112 @default.
- W1969091108 cites W1980993173 @default.
- W1969091108 cites W1981426567 @default.
- W1969091108 cites W1984250381 @default.
- W1969091108 cites W1984580200 @default.
- W1969091108 cites W1988182785 @default.
- W1969091108 cites W1992848717 @default.
- W1969091108 cites W1996355353 @default.
- W1969091108 cites W2003637943 @default.
- W1969091108 cites W2005312734 @default.
- W1969091108 cites W2019104823 @default.
- W1969091108 cites W2022428567 @default.
- W1969091108 cites W2025777039 @default.
- W1969091108 cites W2026380581 @default.
- W1969091108 cites W2036248917 @default.
- W1969091108 cites W2036386995 @default.
- W1969091108 cites W2042070444 @default.
- W1969091108 cites W2044115377 @default.
- W1969091108 cites W2045710903 @default.
- W1969091108 cites W2059725331 @default.
- W1969091108 cites W2061669611 @default.
- W1969091108 cites W2061761689 @default.
- W1969091108 cites W2063176638 @default.
- W1969091108 cites W2063537903 @default.
- W1969091108 cites W2067132703 @default.
- W1969091108 cites W2072167784 @default.
- W1969091108 cites W2073894126 @default.
- W1969091108 cites W2074085543 @default.
- W1969091108 cites W2074167854 @default.
- W1969091108 cites W2075944712 @default.
- W1969091108 cites W2082499403 @default.
- W1969091108 cites W2091214947 @default.
- W1969091108 cites W2096442705 @default.
- W1969091108 cites W2112014931 @default.
- W1969091108 cites W2112632406 @default.
- W1969091108 cites W2127234404 @default.
- W1969091108 cites W2129089298 @default.
- W1969091108 cites W2129146981 @default.
- W1969091108 cites W2130323165 @default.
- W1969091108 cites W2131522485 @default.
- W1969091108 cites W2136012285 @default.
- W1969091108 cites W2136353274 @default.
- W1969091108 cites W2136832023 @default.
- W1969091108 cites W2138375082 @default.
- W1969091108 cites W2140791749 @default.
- W1969091108 cites W2147064753 @default.
- W1969091108 cites W2153947891 @default.
- W1969091108 cites W2154717765 @default.
- W1969091108 cites W2155477793 @default.
- W1969091108 cites W2157504829 @default.
- W1969091108 cites W2165186407 @default.
- W1969091108 cites W2166838096 @default.
- W1969091108 cites W2169477255 @default.
- W1969091108 doi "https://doi.org/10.1074/jbc.m113.478297" @default.
- W1969091108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3774359" @default.
- W1969091108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23740253" @default.
- W1969091108 hasPublicationYear "2013" @default.
- W1969091108 type Work @default.
- W1969091108 sameAs 1969091108 @default.
- W1969091108 citedByCount "174" @default.
- W1969091108 countsByYear W19690911082013 @default.
- W1969091108 countsByYear W19690911082014 @default.
- W1969091108 countsByYear W19690911082015 @default.
- W1969091108 countsByYear W19690911082016 @default.
- W1969091108 countsByYear W19690911082017 @default.
- W1969091108 countsByYear W19690911082018 @default.
- W1969091108 countsByYear W19690911082019 @default.
- W1969091108 countsByYear W19690911082020 @default.
- W1969091108 countsByYear W19690911082021 @default.
- W1969091108 countsByYear W19690911082022 @default.
- W1969091108 countsByYear W19690911082023 @default.
- W1969091108 crossrefType "journal-article" @default.
- W1969091108 hasAuthorship W1969091108A5018892762 @default.
- W1969091108 hasAuthorship W1969091108A5021024576 @default.
- W1969091108 hasAuthorship W1969091108A5046390320 @default.
- W1969091108 hasAuthorship W1969091108A5062771673 @default.
- W1969091108 hasAuthorship W1969091108A5072159508 @default.