Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969093811> ?p ?o ?g. }
- W1969093811 endingPage "348" @default.
- W1969093811 startingPage "336" @default.
- W1969093811 abstract "Abstract The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The DNA damage response (DDR), most robustly mobilized by double‐strand breaks (DSBs), rapidly activates an extensive signaling network that affects numerous cellular systems, leading to cell survival or programmed cell death. A major component of the DDR is the widespread modulation of gene expression. We analyzed together six datasets that probed transcriptional responses to ionizing radiation (IR) – our novel experimental data and 5 published datasets – to elucidate the scope of this response and identify its gene targets. According to the mRNA expression profiles we recorded from 5 cancerous and non‐cancerous human cell lines after exposure to 5 Gy of IR, most of the responses were cell line‐specific. Computational analysis identified significant enrichment for p53 target genes and cell cycle‐related pathways among groups of up‐regulated and down‐regulated genes, respectively. Computational promoter analysis of the six datasets disclosed that a statistically significant number of the induced genes contained p53 binding site signatures. p53‐mediated regulation had previously been documented for subsets of these gene groups, making our lists a source of novel potential p53 targets. Real‐time qPCR and chromatin immunoprecipitation (ChIP) assays validated the IR‐induced p53‐dependent induction and p53 binding to the respective promoters of 11 selected genes. Our results demonstrate the power of a combined computational and experimental approach to identify new transcriptional targets in the DNA damage response network." @default.
- W1969093811 created "2016-06-24" @default.
- W1969093811 creator A5003114911 @default.
- W1969093811 creator A5038806020 @default.
- W1969093811 creator A5043516734 @default.
- W1969093811 creator A5053260181 @default.
- W1969093811 creator A5062893524 @default.
- W1969093811 creator A5065969433 @default.
- W1969093811 creator A5071994598 @default.
- W1969093811 creator A5077703637 @default.
- W1969093811 creator A5082558562 @default.
- W1969093811 creator A5086398854 @default.
- W1969093811 date "2011-07-07" @default.
- W1969093811 modified "2023-09-26" @default.
- W1969093811 title "Transcriptional modulation induced by ionizing radiation: p53 remains a central player" @default.
- W1969093811 cites W1538419182 @default.
- W1969093811 cites W165254100 @default.
- W1969093811 cites W1784517069 @default.
- W1969093811 cites W1964675032 @default.
- W1969093811 cites W1964719993 @default.
- W1969093811 cites W1967482791 @default.
- W1969093811 cites W1968699828 @default.
- W1969093811 cites W1971058391 @default.
- W1969093811 cites W1973788312 @default.
- W1969093811 cites W1974436271 @default.
- W1969093811 cites W1977353123 @default.
- W1969093811 cites W1978282378 @default.
- W1969093811 cites W1980507776 @default.
- W1969093811 cites W1980794648 @default.
- W1969093811 cites W1982742115 @default.
- W1969093811 cites W1983146442 @default.
- W1969093811 cites W1983719481 @default.
- W1969093811 cites W1988524165 @default.
- W1969093811 cites W1988877517 @default.
- W1969093811 cites W1989016400 @default.
- W1969093811 cites W1990146541 @default.
- W1969093811 cites W1991806583 @default.
- W1969093811 cites W1992860902 @default.
- W1969093811 cites W1999541392 @default.
- W1969093811 cites W2001749347 @default.
- W1969093811 cites W2006721912 @default.
- W1969093811 cites W2013165543 @default.
- W1969093811 cites W2014073136 @default.
- W1969093811 cites W2016555559 @default.
- W1969093811 cites W2019663874 @default.
- W1969093811 cites W2020391615 @default.
- W1969093811 cites W2028699785 @default.
- W1969093811 cites W2034059961 @default.
- W1969093811 cites W2035055924 @default.
- W1969093811 cites W2040881358 @default.
- W1969093811 cites W2044961658 @default.
- W1969093811 cites W2047342629 @default.
- W1969093811 cites W2047447041 @default.
- W1969093811 cites W2051870875 @default.
- W1969093811 cites W2055148721 @default.
- W1969093811 cites W2055687679 @default.
- W1969093811 cites W2056601553 @default.
- W1969093811 cites W2061455523 @default.
- W1969093811 cites W2061462200 @default.
- W1969093811 cites W2064420103 @default.
- W1969093811 cites W2067551453 @default.
- W1969093811 cites W2068190109 @default.
- W1969093811 cites W2069781030 @default.
- W1969093811 cites W2072585523 @default.
- W1969093811 cites W2075477596 @default.
- W1969093811 cites W2077436902 @default.
- W1969093811 cites W2078994441 @default.
- W1969093811 cites W2080772875 @default.
- W1969093811 cites W2080933588 @default.
- W1969093811 cites W2082213640 @default.
- W1969093811 cites W2082640307 @default.
- W1969093811 cites W2086301636 @default.
- W1969093811 cites W2086333179 @default.
- W1969093811 cites W2086756536 @default.
- W1969093811 cites W2088754604 @default.
- W1969093811 cites W2088857928 @default.
- W1969093811 cites W2091073356 @default.
- W1969093811 cites W2093677239 @default.
- W1969093811 cites W2093751544 @default.
- W1969093811 cites W2098132781 @default.
- W1969093811 cites W2101334433 @default.
- W1969093811 cites W2102550616 @default.
- W1969093811 cites W2105325784 @default.
- W1969093811 cites W2106624609 @default.
- W1969093811 cites W2108482850 @default.
- W1969093811 cites W2112651502 @default.
- W1969093811 cites W2115013649 @default.
- W1969093811 cites W2119281341 @default.
- W1969093811 cites W2123299380 @default.
- W1969093811 cites W2128399345 @default.
- W1969093811 cites W2132396299 @default.
- W1969093811 cites W2137575413 @default.
- W1969093811 cites W2137672139 @default.
- W1969093811 cites W2138544876 @default.
- W1969093811 cites W2139777089 @default.
- W1969093811 cites W2141326128 @default.
- W1969093811 cites W2143129603 @default.
- W1969093811 cites W2145200068 @default.