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• W1969104098 endingPage "397" @default.
• W1969104098 startingPage "387" @default.
• W1969104098 abstract "The ADH4 gene, which encodes human pi-alcohol dehydrogenase, is expressed in a tissue-specific manner, with the highest level in liver and lower levels in the gastrointestinal tract. We examined the location and function of the cis-acting elements that regulate ADH4 transcription. Liver contains proteins that bound to seven sites in the proximal promoter (from bp -387 to bp +17). Proteins from other tissues bound to subsets of these sites and to two additional sites, one of which is a negative cis-acting element. Members of two important transcription factor families, C/EBP and AP-1, bound to several sites in this promoter. The proximal ADH4 promoter functioned in a hepatoma cell line (H4IIE-C3) and a kidney cell line (CV-1). Coexpression of members of the C/EBP family strongly enhanced promoter activity, which can in part explain the high level of expression of ADH4 in liver. At one site that can be bound by both C/EBP and c-Jun, a mutation that abolished binding by C/EBP but not by c-Jun decreased promoter activity in both cell lines. This mutation had a stronger effect in the context of a longer promoter, suggesting interaction among cis-acting elements." @default.
• W1969104098 created "2016-06-24" @default.
• W1969104098 creator A5009884211 @default.
• W1969104098 creator A5044635265 @default.
• W1969104098 date "1998-04-01" @default.
• W1969104098 modified "2023-10-06" @default.
• W1969104098 title "Function of<i>cis</i>-Acting Elements in Human Alcohol Dehydrogenase 4 (<i>ADH4</i>) Promoter and Role of C/EBP Proteins in Gene Expression" @default.
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• W1969104098 doi "https://doi.org/10.1089/dna.1998.17.387" @default.
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