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• W1969107046 abstract "Major findings with regard to the somatostatin-growth hormone (GH)-insulin-like growth factor (IGF-1) axis and diabetes are summarized. GH hypersecretion and reduced circulating IGF-1 levels are prevalent in insulin-dependent diabetes. Somatostatin improves metabolism in insulin-dependent diabetics. Insulin resistance and poor metabolic regulation, which may partly be due to hypersecretion of GH, are believed to accelerate the development of diabetic angiopathy. Diabetic hypersomatotrophinemia may be due to hepatic resistance to GH and increased hepatic production of IGF-1-binding protein-1 (IGFBP-1), leading to reduced levels of circulating IGF-1 and further stimulation of GH production. Studies in vitro and in diabetics suggest a causal link between diabetic hypersomatotrophinemia and diabetic angiopathy. In vitro evidence for the involvement of IGF-1 in diabetic angiopathy is reviewed. Also reviewed is evidence, from rat and human studies, of the possible involvement of GH and IGF-1 in diabetic nephropathy. The role of somatostatin in late diabetic vascular complications remains to be elucidated." @default.
• W1969107046 created "2016-06-24" @default.
• W1969107046 creator A5083229910 @default.
• W1969107046 date "1996-08-01" @default.
• W1969107046 modified "2023-10-18" @default.
• W1969107046 title "Somatostatin, growth hormone, insulin-like growth factor-1, and diabetes: Friends or foes?" @default.
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• W1969107046 doi "https://doi.org/10.1016/s0026-0495(96)90094-3" @default.
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• W1969107046 hasPublicationYear "1996" @default.
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