Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969115004> ?p ?o ?g. }
- W1969115004 endingPage "852" @default.
- W1969115004 startingPage "842" @default.
- W1969115004 abstract "Summary Purpose: This study investigated putative correlations among behavioral changes and: (1) neuronal loss, (2) hippocampal mossy fiber sprouting, and (3) reactive astrogliosis in adult rats submitted to early‐life LiCl‐pilocarpine‐induced status epilepticus (SE). Methods: Rats (P15) received LiCl (3 mEq/kg, i.p.) 12–18 h prior pilocarpine (60 mg/kg; s.c.). At adulthood, animals were submitted to behavioral tasks and after the completion of tasks biochemical and histological analysis were performed. Results: In SE group, it was observed an increased number of degenerating neurons in the CA1 subfield and in the hilus of animals 24 h after SE. At adulthood, SE group presented an aversive memory deficit in an inhibitory avoidance task and the animals that presented lower latency to the step down showed a higher score for mossy fiber sprouting. In the light‐dark exploration task, SE rats returned less and spent less time in the light compartment and present an increased number of risk assessment behavior (RA). There was a negative correlation between the time spent in the light compartment and the score for mossy fiber sprouting and a positive correlation between score for mossy fiber sprouting and number of RA. LiCl‐pilocarpine‐treated animals showed higher levels of S100B immunocontent in the CSF as well as a positive correlation between the score for sprouting and the GFAP immunocontent in the CA1 subfield, suggesting an astrocytic response to neuronal injury. Conclusions: We showed that LiCl‐pilocarpine‐induced SE during development produced long‐lasting behavioral abnormalities, which might be associated with mossy fiber sprouting and elevated CSF S100B levels at adulthood." @default.
- W1969115004 created "2016-06-24" @default.
- W1969115004 creator A5002453524 @default.
- W1969115004 creator A5002744170 @default.
- W1969115004 creator A5017522426 @default.
- W1969115004 creator A5032938622 @default.
- W1969115004 creator A5036441151 @default.
- W1969115004 creator A5039543497 @default.
- W1969115004 creator A5053955014 @default.
- W1969115004 creator A5061328350 @default.
- W1969115004 creator A5061988743 @default.
- W1969115004 creator A5089170099 @default.
- W1969115004 date "2008-02-07" @default.
- W1969115004 modified "2023-10-18" @default.
- W1969115004 title "Effects of early-life LiCl-Pilocarpine-induced status epilepticus on memory and anxiety in adult rats are associated with mossy fiber sprouting and elevated CSF S100B protein" @default.
- W1969115004 cites W1163697721 @default.
- W1969115004 cites W1487386905 @default.
- W1969115004 cites W1592119898 @default.
- W1969115004 cites W1827373965 @default.
- W1969115004 cites W1874385193 @default.
- W1969115004 cites W1951602267 @default.
- W1969115004 cites W1970958687 @default.
- W1969115004 cites W1974210177 @default.
- W1969115004 cites W1981870110 @default.
- W1969115004 cites W1982687529 @default.
- W1969115004 cites W1990369912 @default.
- W1969115004 cites W1994168787 @default.
- W1969115004 cites W1998826717 @default.
- W1969115004 cites W2002085774 @default.
- W1969115004 cites W2003421769 @default.
- W1969115004 cites W2005427699 @default.
- W1969115004 cites W2011109576 @default.
- W1969115004 cites W2025540461 @default.
- W1969115004 cites W2035892706 @default.
- W1969115004 cites W2043851570 @default.
- W1969115004 cites W2063938540 @default.
- W1969115004 cites W2070301880 @default.
- W1969115004 cites W2073007581 @default.
- W1969115004 cites W2073087209 @default.
- W1969115004 cites W2074137171 @default.
- W1969115004 cites W2075169103 @default.
- W1969115004 cites W2076394931 @default.
- W1969115004 cites W2078333644 @default.
- W1969115004 cites W2079133060 @default.
- W1969115004 cites W2088017716 @default.
- W1969115004 cites W2089246031 @default.
- W1969115004 cites W2124336860 @default.
- W1969115004 cites W2137454981 @default.
- W1969115004 cites W2138152051 @default.
- W1969115004 cites W2141041835 @default.
- W1969115004 cites W2150357694 @default.
- W1969115004 cites W2168660234 @default.
- W1969115004 cites W2168814838 @default.
- W1969115004 cites W2169798330 @default.
- W1969115004 cites W2171584675 @default.
- W1969115004 cites W4240989554 @default.
- W1969115004 doi "https://doi.org/10.1111/j.1528-1167.2007.01484.x" @default.
- W1969115004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18177363" @default.
- W1969115004 hasPublicationYear "2008" @default.
- W1969115004 type Work @default.
- W1969115004 sameAs 1969115004 @default.
- W1969115004 citedByCount "43" @default.
- W1969115004 countsByYear W19691150042012 @default.
- W1969115004 countsByYear W19691150042013 @default.
- W1969115004 countsByYear W19691150042014 @default.
- W1969115004 countsByYear W19691150042015 @default.
- W1969115004 countsByYear W19691150042016 @default.
- W1969115004 countsByYear W19691150042017 @default.
- W1969115004 countsByYear W19691150042018 @default.
- W1969115004 countsByYear W19691150042019 @default.
- W1969115004 countsByYear W19691150042020 @default.
- W1969115004 countsByYear W19691150042021 @default.
- W1969115004 countsByYear W19691150042022 @default.
- W1969115004 countsByYear W19691150042023 @default.
- W1969115004 crossrefType "journal-article" @default.
- W1969115004 hasAuthorship W1969115004A5002453524 @default.
- W1969115004 hasAuthorship W1969115004A5002744170 @default.
- W1969115004 hasAuthorship W1969115004A5017522426 @default.
- W1969115004 hasAuthorship W1969115004A5032938622 @default.
- W1969115004 hasAuthorship W1969115004A5036441151 @default.
- W1969115004 hasAuthorship W1969115004A5039543497 @default.
- W1969115004 hasAuthorship W1969115004A5053955014 @default.
- W1969115004 hasAuthorship W1969115004A5061328350 @default.
- W1969115004 hasAuthorship W1969115004A5061988743 @default.
- W1969115004 hasAuthorship W1969115004A5089170099 @default.
- W1969115004 hasConcept C126322002 @default.
- W1969115004 hasConcept C134018914 @default.
- W1969115004 hasConcept C148762608 @default.
- W1969115004 hasConcept C15744967 @default.
- W1969115004 hasConcept C169760540 @default.
- W1969115004 hasConcept C2776464000 @default.
- W1969115004 hasConcept C2777204577 @default.
- W1969115004 hasConcept C2777318268 @default.
- W1969115004 hasConcept C2777341932 @default.
- W1969115004 hasConcept C2778186239 @default.
- W1969115004 hasConcept C2778241760 @default.
- W1969115004 hasConcept C2779965356 @default.
- W1969115004 hasConcept C2781161787 @default.