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• W1969117624 startingPage "853" @default.
• W1969117624 abstract "The heterogeneous nuclear ribonucleoprotein (hnRNP) F is involved in the regulation of mRNA metabolism by specifically recognizing G-tract RNA sequences. We have determined the solution structures of the three quasi-RNA-recognition motifs (qRRMs) of hnRNP F in complex with G-tract RNA. These structures show that qRRMs bind RNA in a very unusual manner, with the G-tract 'encaged', making the qRRM a novel RNA binding domain. We defined a consensus signature sequence for qRRMs and identified other human qRRM-containing proteins that also specifically recognize G-tract RNAs. Our structures explain how qRRMs can sequester G-tracts, maintaining them in a single-stranded conformation. We also show that isolated qRRMs of hnRNP F are sufficient to regulate the alternative splicing of the Bcl-x pre-mRNA, suggesting that hnRNP F would act by remodeling RNA secondary and tertiary structures." @default.
• W1969117624 created "2016-06-24" @default.
• W1969117624 creator A5000950151 @default.
• W1969117624 creator A5043676151 @default.
• W1969117624 creator A5075671745 @default.
• W1969117624 creator A5088099050 @default.
• W1969117624 date "2010-06-06" @default.
• W1969117624 modified "2023-10-16" @default.
• W1969117624 title "Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs" @default.
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• W1969117624 doi "https://doi.org/10.1038/nsmb.1814" @default.
• W1969117624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20526337" @default.
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