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• W1969124490 endingPage "116" @default.
• W1969124490 startingPage "111" @default.
• W1969124490 abstract "Background: Denture base acrylic resin is easily colonised by oral endogenous bacteria and Candida spp., and eventually by extra‐oral species such as Staphylococcus spp., Pseudomonadaceae or members of Enterobacteriaceae . This microbial reservoir can be responsive for denture related stomatitis and aspiration pneumonia, a life‐threatening infection especially in geriatric patients. However, the oral and denture hygiene of dependant elderly individuals is extremely poor. Objective: This in vitro study aimed to determine the per cent of a quaternary ammonium compound heat‐polymerised in acrylic resin necessary to obtain denture base displaying antiseptic properties. Design: Acrylic resin discs containing 2–50% ammonium polymer (Poly 202063A; 0% control) were soaked in artificial saliva for 4 weeks. Resin discs were incubated for 24 hours with Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa [37°C, brain–heart infusion (BHI) broth and phosphate‐buffered saline (PBS) buffer] and Candida albicans (30°C, Schaedler broth), in 15 ml (168 discs) and 600 μ l (168 discs) of inoculum. Microbial growth was verified at t 0 hours and t 24 hours. Data were recorded as the mean of three colony forming unit (CFU) numerations. The borderline of antimicrobial effect was determined at 0.1% viable cells. Results: In 600 μ l of PBS inoculum, resin specimens had a bactericidal effect ( E. coli and S. aureus : 2%; P. aeruginosa : 10%) and a fungicidal effect ( C. albicans : 50%). Long‐term stability and toxicity in vivo studies are now required. Conclusion: A 2% quaternary ammonium compound polymerised with a denture acrylic resin displayed antiseptic properties after a 4‐week soaking period in artificial saliva. Such antiseptic denture base could help geriatric patients to improve their oral health." @default.
• W1969124490 created "2016-06-24" @default.
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• W1969124490 date "2006-05-05" @default.
• W1969124490 modified "2023-10-11" @default.
• W1969124490 title "In vitro antiseptic properties of an ammonium compound combined with denture base acrylic resin" @default.
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• W1969124490 doi "https://doi.org/10.1111/j.1741-2358.2006.00088.x" @default.
• W1969124490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16677185" @default.
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