FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969131543> ?p ?o ?g. }

• W1969131543 endingPage "860" @default.
• W1969131543 startingPage "849" @default.
• W1969131543 abstract "Ischemic damage to the retina is a multifaceted process that results in irreversible loss of ganglion cells and blinding disease. Although the mechanisms underlying ischemia-induced ganglion cell death in the retina are not clearly understood, we have recently reported that retinal damage induced by ligation of the optic nerve results in increased matrix metalloproteinase-9 (MMP-9) synthesis and promotes ganglion cell loss. In this study, we have investigated the roles of IL-1beta and mitogen activated protein kinases in MMP-9 induction in the retina. Optic nerve ligation led to a transient increase in IL-1beta and MMP-9 levels and phosphorylation of p42/p44 mitogen activated protein kinases (extracellular signal-regulated kinases, ERK1 and ERK2) in the retina. We found no significant increase in phosphorylation of p38 MAP kinase or c-jun N-terminal kinases indicating that ERK1/2 plays a major role in MMP-9 induction. Intravitreal injection of IL-1 receptor antagonist (IL-1Ra) or MAP kinase inhibitor U0126 significantly decreased both ERK1/2 phosphorylation and MMP-9 induction suggesting that interruption of this cascade might attenuate retinal damage. In support of this, intravitreal injection of IL-1Ra and U0126 offered significant protection against optic nerve-induced retinal damage. These results suggest that optic nerve ligation-induced IL-1beta promotes retinal damage by increasing MMP-9 synthesis in the retina." @default.
• W1969131543 created "2016-06-24" @default.
• W1969131543 creator A5051409764 @default.
• W1969131543 creator A5073568638 @default.
• W1969131543 date "2004-04-01" @default.
• W1969131543 modified "2023-10-05" @default.
• W1969131543 title "Influence of interleukin-1 beta induction and mitogen-activated protein kinase phosphorylation on optic nerve ligation-induced matrix metalloproteinase-9 activation in the retina" @default.
• W1969131543 cites W14550876 @default.
• W1969131543 cites W1496877897 @default.
• W1969131543 cites W1504288624 @default.
• W1969131543 cites W1530284699 @default.
• W1969131543 cites W1558237074 @default.
• W1969131543 cites W1565493424 @default.
• W1969131543 cites W1572174728 @default.
• W1969131543 cites W1598606175 @default.
• W1969131543 cites W1623264536 @default.
• W1969131543 cites W1624526296 @default.
• W1969131543 cites W169514863 @default.
• W1969131543 cites W1899552864 @default.
• W1969131543 cites W1955881853 @default.
• W1969131543 cites W1968905163 @default.
• W1969131543 cites W1976385326 @default.
• W1969131543 cites W1976858755 @default.
• W1969131543 cites W1981680830 @default.
• W1969131543 cites W1982592829 @default.
• W1969131543 cites W1984466510 @default.
• W1969131543 cites W1986010238 @default.
• W1969131543 cites W1988327100 @default.
• W1969131543 cites W1990711278 @default.
• W1969131543 cites W1996886208 @default.
• W1969131543 cites W1996916653 @default.
• W1969131543 cites W1997510003 @default.
• W1969131543 cites W2003023154 @default.
• W1969131543 cites W2005707246 @default.
• W1969131543 cites W2011349107 @default.
• W1969131543 cites W2011875859 @default.
• W1969131543 cites W2012066718 @default.
• W1969131543 cites W2021353301 @default.
• W1969131543 cites W2022592499 @default.
• W1969131543 cites W2022671065 @default.
• W1969131543 cites W2022959705 @default.
• W1969131543 cites W2023396428 @default.
• W1969131543 cites W2029378364 @default.
• W1969131543 cites W2030683040 @default.
• W1969131543 cites W2032873707 @default.
• W1969131543 cites W2033537576 @default.
• W1969131543 cites W2043033966 @default.
• W1969131543 cites W2048047884 @default.
• W1969131543 cites W2057512153 @default.
• W1969131543 cites W2061447912 @default.
• W1969131543 cites W2061642062 @default.
• W1969131543 cites W2062567347 @default.
• W1969131543 cites W2063580118 @default.
• W1969131543 cites W2064243077 @default.
• W1969131543 cites W2066963022 @default.
• W1969131543 cites W2072585950 @default.
• W1969131543 cites W2082011784 @default.
• W1969131543 cites W2082392681 @default.
• W1969131543 cites W2090459889 @default.
• W1969131543 cites W2093421292 @default.
• W1969131543 cites W2093629370 @default.
• W1969131543 cites W2098752487 @default.
• W1969131543 cites W2099151597 @default.
• W1969131543 cites W2103046674 @default.
• W1969131543 cites W2104526708 @default.
• W1969131543 cites W2113892795 @default.
• W1969131543 cites W2142848667 @default.
• W1969131543 cites W2149364554 @default.
• W1969131543 cites W2157360196 @default.
• W1969131543 cites W2164082697 @default.
• W1969131543 cites W2292619439 @default.
• W1969131543 cites W45806187 @default.
• W1969131543 doi "https://doi.org/10.1016/j.exer.2003.10.018" @default.
• W1969131543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15037119" @default.
• W1969131543 hasPublicationYear "2004" @default.
• W1969131543 type Work @default.
• W1969131543 sameAs 1969131543 @default.
• W1969131543 citedByCount "40" @default.
• W1969131543 countsByYear W19691315432012 @default.
• W1969131543 countsByYear W19691315432013 @default.
• W1969131543 countsByYear W19691315432014 @default.
• W1969131543 countsByYear W19691315432015 @default.
• W1969131543 countsByYear W19691315432016 @default.
• W1969131543 countsByYear W19691315432017 @default.
• W1969131543 countsByYear W19691315432019 @default.
• W1969131543 countsByYear W19691315432020 @default.
• W1969131543 countsByYear W19691315432021 @default.
• W1969131543 countsByYear W19691315432022 @default.
• W1969131543 countsByYear W19691315432023 @default.
• W1969131543 crossrefType "journal-article" @default.
• W1969131543 hasAuthorship W1969131543A5051409764 @default.
• W1969131543 hasAuthorship W1969131543A5073568638 @default.
• W1969131543 hasConcept C11960822 @default.
• W1969131543 hasConcept C132149769 @default.
• W1969131543 hasConcept C169760540 @default.
• W1969131543 hasConcept C184235292 @default.
• W1969131543 hasConcept C185592680 @default.
• W1969131543 hasConcept C2777093970 @default.

• next