FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969131663> ?p ?o ?g. }

• W1969131663 endingPage "E1377" @default.
• W1969131663 startingPage "E1366" @default.
• W1969131663 abstract "Renal protection against diabetes-induced pathogenic injuries by multiple exposures to low-dose radiation (LDR) was investigated to develop a novel approach to the prevention of renal disease for diabetic subjects. C57BL/6J mice were given multiple low-dose streptozotocin (STZ; 60 × 6 mg/kg) to produce a type 1 diabetes. Two weeks after diabetes onset, some of diabetic mice and age-matched nondiabetic mice were exposed whole body to 25 mGy X-rays every other day for 2, 4, 8, 12, and 16 wk. Diabetes caused a significant renal dysfunction, shown by time-dependent increase in urinary microalbumin (Malb) and decrease in urinary creatinine (Cre), and pathological changes, shown by significant increases in renal structural changes and PAS-positive staining. However, diabetes-induced renal dysfunction and pathological changes were significantly, albeit partially, attenuated by multiple exposures to LDR. Furthermore, LDR protection against diabetes-induced renal dysfunction and pathological changes was associated with a significant suppression of diabetes-increased systemic and renal inflammation, shown by significant increases in serum and renal TNFα, ICAM-1, IL-18, MCP-1, and PAI-1 contents. To further explore the mechanism by which LDR prevents diabetes-induced renal pathological changes, renal oxidative damage was examined by Western blotting and immunohistochemical staining for 3-nitrotyrosine and 4-hydroxynonenal. Significant increase in oxidative damage was observed in diabetic mice, but not diabetic mice, with LDR. Renal fibrosis, examined by Western blotting of connective tissue growth factor and Masson's trichrome staining, was also evident in the kidneys of diabetic mice but not diabetic mice with LDR. These results suggest that multiple exposures to LDR significantly suppress diabetes-induced systemic and renal inflammatory response and renal oxidative damage, resulting in a prevention of the renal dysfunction and fibrosis." @default.
• W1969131663 created "2016-06-24" @default.
• W1969131663 creator A5014656305 @default.
• W1969131663 creator A5017873319 @default.
• W1969131663 creator A5017927015 @default.
• W1969131663 creator A5018353312 @default.
• W1969131663 creator A5022407487 @default.
• W1969131663 creator A5046839995 @default.
• W1969131663 creator A5069355534 @default.
• W1969131663 date "2009-12-01" @default.
• W1969131663 modified "2023-09-27" @default.
• W1969131663 title "Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation" @default.
• W1969131663 cites W1973246225 @default.
• W1969131663 cites W1973651950 @default.
• W1969131663 cites W1984025588 @default.
• W1969131663 cites W1990143854 @default.
• W1969131663 cites W1991489747 @default.
• W1969131663 cites W1996610877 @default.
• W1969131663 cites W2004705341 @default.
• W1969131663 cites W2005085512 @default.
• W1969131663 cites W2007529113 @default.
• W1969131663 cites W2010818019 @default.
• W1969131663 cites W2012194625 @default.
• W1969131663 cites W2015837920 @default.
• W1969131663 cites W2028615837 @default.
• W1969131663 cites W2044554811 @default.
• W1969131663 cites W2045640058 @default.
• W1969131663 cites W2051616579 @default.
• W1969131663 cites W2059107132 @default.
• W1969131663 cites W2064535158 @default.
• W1969131663 cites W2089781183 @default.
• W1969131663 cites W2097253300 @default.
• W1969131663 cites W2098849565 @default.
• W1969131663 cites W2100784997 @default.
• W1969131663 cites W2101894634 @default.
• W1969131663 cites W2108192985 @default.
• W1969131663 cites W2108359388 @default.
• W1969131663 cites W2116905348 @default.
• W1969131663 cites W2122182311 @default.
• W1969131663 cites W2129649326 @default.
• W1969131663 cites W2144914973 @default.
• W1969131663 cites W2150724109 @default.
• W1969131663 cites W2153092921 @default.
• W1969131663 cites W2153140006 @default.
• W1969131663 cites W2158200096 @default.
• W1969131663 cites W2158550605 @default.
• W1969131663 cites W2166602064 @default.
• W1969131663 cites W2169573863 @default.
• W1969131663 cites W2170715598 @default.
• W1969131663 cites W2171741318 @default.
• W1969131663 doi "https://doi.org/10.1152/ajpendo.00478.2009" @default.
• W1969131663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19789291" @default.
• W1969131663 hasPublicationYear "2009" @default.
• W1969131663 type Work @default.
• W1969131663 sameAs 1969131663 @default.
• W1969131663 citedByCount "28" @default.
• W1969131663 countsByYear W19691316632012 @default.
• W1969131663 countsByYear W19691316632013 @default.
• W1969131663 countsByYear W19691316632014 @default.
• W1969131663 countsByYear W19691316632015 @default.
• W1969131663 countsByYear W19691316632016 @default.
• W1969131663 countsByYear W19691316632017 @default.
• W1969131663 countsByYear W19691316632018 @default.
• W1969131663 countsByYear W19691316632019 @default.
• W1969131663 countsByYear W19691316632023 @default.
• W1969131663 crossrefType "journal-article" @default.
• W1969131663 hasAuthorship W1969131663A5014656305 @default.
• W1969131663 hasAuthorship W1969131663A5017873319 @default.
• W1969131663 hasAuthorship W1969131663A5017927015 @default.
• W1969131663 hasAuthorship W1969131663A5018353312 @default.
• W1969131663 hasAuthorship W1969131663A5022407487 @default.
• W1969131663 hasAuthorship W1969131663A5046839995 @default.
• W1969131663 hasAuthorship W1969131663A5069355534 @default.
• W1969131663 hasConcept C126322002 @default.
• W1969131663 hasConcept C134018914 @default.
• W1969131663 hasConcept C163031210 @default.
• W1969131663 hasConcept C2777622882 @default.
• W1969131663 hasConcept C2779280383 @default.
• W1969131663 hasConcept C2779385521 @default.
• W1969131663 hasConcept C2780091579 @default.
• W1969131663 hasConcept C2780559512 @default.
• W1969131663 hasConcept C519581460 @default.
• W1969131663 hasConcept C555293320 @default.
• W1969131663 hasConcept C71924100 @default.
• W1969131663 hasConcept C77411442 @default.
• W1969131663 hasConceptScore W1969131663C126322002 @default.
• W1969131663 hasConceptScore W1969131663C134018914 @default.
• W1969131663 hasConceptScore W1969131663C163031210 @default.
• W1969131663 hasConceptScore W1969131663C2777622882 @default.
• W1969131663 hasConceptScore W1969131663C2779280383 @default.
• W1969131663 hasConceptScore W1969131663C2779385521 @default.
• W1969131663 hasConceptScore W1969131663C2780091579 @default.
• W1969131663 hasConceptScore W1969131663C2780559512 @default.
• W1969131663 hasConceptScore W1969131663C519581460 @default.
• W1969131663 hasConceptScore W1969131663C555293320 @default.
• W1969131663 hasConceptScore W1969131663C71924100 @default.
• W1969131663 hasConceptScore W1969131663C77411442 @default.
• W1969131663 hasIssue "6" @default.

• next