FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969131672> ?p ?o ?g. }

• W1969131672 endingPage "43" @default.
• W1969131672 startingPage "34" @default.
• W1969131672 abstract "Metabolite profiling by NMR of body fluids is increasingly used to successfully differentiate patients from healthy individuals. Metabolites and their concentrations are direct reporters of body biochemistry. However, in blood plasma the NMR-detected free-metabolite concentrations are also strongly affected by interactions with the abundant plasma proteins, which have as of yet not been considered much in metabolic profiling. We previously reported that many of the common NMR-detected metabolites in blood plasma bind to human serum albumin (HSA) and many are released by fatty acids present in fatted HSA. HSA is the most abundant plasma protein and main transporter of endogenous and exogenous metabolites. Here, we show by NMR how the two most common fatty acids (FAs) in blood plasma – the long-chain FA, stearate (C18:0) and medium-chain FA, myristate (C14:0) – affect metabolite–HSA interaction. Of the set of 18 common NMR-detected metabolites, many are released by stearate and/or myristate, lactate appearing the most strongly affected. Myristate, but not stearate, reduces HSA-binding of phenylalanine and pyruvate. Citrate signals were NMR invisible in the presence of HSA. Only at high myristate–HSA mole ratios 11:1, is citrate sufficiently released to be detected. Finally, we find that limited dilution of blood-plasma mimics releases HSA-bound metabolites, a finding confirmed in real blood plasma samples. Based on these findings, we provide recommendations for NMR experiments for quantitative metabolite profiling." @default.
• W1969131672 created "2016-06-24" @default.
• W1969131672 creator A5012288587 @default.
• W1969131672 creator A5026388073 @default.
• W1969131672 creator A5051959618 @default.
• W1969131672 creator A5074918663 @default.
• W1969131672 creator A5091277743 @default.
• W1969131672 date "2014-02-01" @default.
• W1969131672 modified "2023-10-12" @default.
• W1969131672 title "NMR metabolomics profiling of blood plasma mimics shows that medium- and long-chain fatty acids differently release metabolites from human serum albumin" @default.
• W1969131672 cites W1544339897 @default.
• W1969131672 cites W1560376606 @default.
• W1969131672 cites W1575542562 @default.
• W1969131672 cites W1592584230 @default.
• W1969131672 cites W1964493191 @default.
• W1969131672 cites W1968813090 @default.
• W1969131672 cites W1969471102 @default.
• W1969131672 cites W1973950263 @default.
• W1969131672 cites W1980078657 @default.
• W1969131672 cites W1980544438 @default.
• W1969131672 cites W1986966205 @default.
• W1969131672 cites W1992029609 @default.
• W1969131672 cites W1997295916 @default.
• W1969131672 cites W2002731325 @default.
• W1969131672 cites W2004985832 @default.
• W1969131672 cites W2007067779 @default.
• W1969131672 cites W2013607204 @default.
• W1969131672 cites W2014477053 @default.
• W1969131672 cites W2015489056 @default.
• W1969131672 cites W2016401253 @default.
• W1969131672 cites W2017215225 @default.
• W1969131672 cites W2017654147 @default.
• W1969131672 cites W2018811823 @default.
• W1969131672 cites W2027762699 @default.
• W1969131672 cites W2031357416 @default.
• W1969131672 cites W2032770289 @default.
• W1969131672 cites W2036187452 @default.
• W1969131672 cites W2036283496 @default.
• W1969131672 cites W2041146832 @default.
• W1969131672 cites W2041780922 @default.
• W1969131672 cites W2045474927 @default.
• W1969131672 cites W2046541538 @default.
• W1969131672 cites W2051586950 @default.
• W1969131672 cites W2053585277 @default.
• W1969131672 cites W2058241083 @default.
• W1969131672 cites W2058526931 @default.
• W1969131672 cites W2068976071 @default.
• W1969131672 cites W2071534982 @default.
• W1969131672 cites W2072351322 @default.
• W1969131672 cites W2076283593 @default.
• W1969131672 cites W2076755375 @default.
• W1969131672 cites W2077055938 @default.
• W1969131672 cites W2079733567 @default.
• W1969131672 cites W2084823796 @default.
• W1969131672 cites W2088900329 @default.
• W1969131672 cites W2090427843 @default.
• W1969131672 cites W2093021792 @default.
• W1969131672 cites W2104709532 @default.
• W1969131672 cites W2104825836 @default.
• W1969131672 cites W2117314219 @default.
• W1969131672 cites W2119724249 @default.
• W1969131672 cites W2130382164 @default.
• W1969131672 cites W2154631167 @default.
• W1969131672 cites W4243378604 @default.
• W1969131672 doi "https://doi.org/10.1016/j.jmr.2013.11.019" @default.
• W1969131672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24374750" @default.
• W1969131672 hasPublicationYear "2014" @default.
• W1969131672 type Work @default.
• W1969131672 sameAs 1969131672 @default.
• W1969131672 citedByCount "20" @default.
• W1969131672 countsByYear W19691316722014 @default.
• W1969131672 countsByYear W19691316722015 @default.
• W1969131672 countsByYear W19691316722016 @default.
• W1969131672 countsByYear W19691316722017 @default.
• W1969131672 countsByYear W19691316722018 @default.
• W1969131672 countsByYear W19691316722019 @default.
• W1969131672 countsByYear W19691316722020 @default.
• W1969131672 countsByYear W19691316722021 @default.
• W1969131672 countsByYear W19691316722022 @default.
• W1969131672 crossrefType "journal-article" @default.
• W1969131672 hasAuthorship W1969131672A5012288587 @default.
• W1969131672 hasAuthorship W1969131672A5026388073 @default.
• W1969131672 hasAuthorship W1969131672A5051959618 @default.
• W1969131672 hasAuthorship W1969131672A5074918663 @default.
• W1969131672 hasAuthorship W1969131672A5091277743 @default.
• W1969131672 hasConcept C135870905 @default.
• W1969131672 hasConcept C146543888 @default.
• W1969131672 hasConcept C165616093 @default.
• W1969131672 hasConcept C178790620 @default.
• W1969131672 hasConcept C185592680 @default.
• W1969131672 hasConcept C21565614 @default.
• W1969131672 hasConcept C2776125364 @default.
• W1969131672 hasConcept C2776575606 @default.
• W1969131672 hasConcept C2777477808 @default.
• W1969131672 hasConcept C2778597219 @default.
• W1969131672 hasConcept C2779671005 @default.
• W1969131672 hasConcept C43617362 @default.
• W1969131672 hasConcept C543025807 @default.

• next