FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969132378> ?p ?o ?g. }

• W1969132378 endingPage "714" @default.
• W1969132378 startingPage "707" @default.
• W1969132378 abstract "During mitochondrial replication, spontaneous mutations occur and accumulate asymmetrically during the time spent single stranded by the heavy strand (DssH). The predominant mutations appear to be deaminations from adenine to hypoxanthine (A --> H, which leads to an A --> G substitution) and cytosine to thymine (C --> T). Previous findings indicated that C --> T substitutions accumulate rapidly and then saturate at high DssH, suggesting protection or repair, whereas A --> G accumulates linearly with DssH. We describe here the implementation of a simple hidden Markov model (HMM) of among-site rate correlations to provide an almost continuous profile of the asymmetry in substitution response for any particular substitution type. We implement this model using a phylogeny-based Bayesian Markov chain Monte Carlo (MCMC) approach. We compare and contrast the relative asymmetries in all 12 possible substitution types, and find that the observed transition substitution responses determined using our new method agree quite well with previous predictions of a saturating curve for C --> T transition substitutions and a linear accumulation of A --> G transitions. The patterns seen in transversion substitutions show much lower among-site variation, and are nonlinear and more complex than those seen in transitions. We also find that, after accounting for the principal linear effect, some of the residual variation in A --> G/G --> A response ratios is explained by the average predicted nucleic acid secondary structure propensity at a site, possibly due to protection from mutation when secondary structure forms." @default.
• W1969132378 created "2016-06-24" @default.
• W1969132378 creator A5002722506 @default.
• W1969132378 creator A5029592340 @default.
• W1969132378 creator A5044699527 @default.
• W1969132378 creator A5091820929 @default.
• W1969132378 date "2004-10-01" @default.
• W1969132378 modified "2023-10-14" @default.
• W1969132378 title "Detecting Gradients of Asymmetry in Site-Specific Substitutions in Mitochondrial Genomes" @default.
• W1969132378 cites W1765516395 @default.
• W1969132378 cites W1896813084 @default.
• W1969132378 cites W1976031348 @default.
• W1969132378 cites W1979277579 @default.
• W1969132378 cites W1979373959 @default.
• W1969132378 cites W1997763580 @default.
• W1969132378 cites W1997939158 @default.
• W1969132378 cites W1998498679 @default.
• W1969132378 cites W2001967468 @default.
• W1969132378 cites W2003447082 @default.
• W1969132378 cites W2021308167 @default.
• W1969132378 cites W2024034891 @default.
• W1969132378 cites W2031497157 @default.
• W1969132378 cites W2036163118 @default.
• W1969132378 cites W2046299964 @default.
• W1969132378 cites W2046993694 @default.
• W1969132378 cites W2053929098 @default.
• W1969132378 cites W2056760934 @default.
• W1969132378 cites W2061140759 @default.
• W1969132378 cites W2061646041 @default.
• W1969132378 cites W2063239546 @default.
• W1969132378 cites W2063873651 @default.
• W1969132378 cites W2077311097 @default.
• W1969132378 cites W2092375131 @default.
• W1969132378 cites W2106882534 @default.
• W1969132378 cites W2108034499 @default.
• W1969132378 cites W2123696055 @default.
• W1969132378 cites W2126606792 @default.
• W1969132378 cites W2131703491 @default.
• W1969132378 cites W2132576704 @default.
• W1969132378 cites W2137188869 @default.
• W1969132378 cites W2138309709 @default.
• W1969132378 cites W2141157874 @default.
• W1969132378 cites W2155734003 @default.
• W1969132378 cites W2161116308 @default.
• W1969132378 cites W2161489217 @default.
• W1969132378 cites W2166302108 @default.
• W1969132378 doi "https://doi.org/10.1089/dna.2004.23.707" @default.
• W1969132378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2943950" @default.
• W1969132378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15585129" @default.
• W1969132378 hasPublicationYear "2004" @default.
• W1969132378 type Work @default.
• W1969132378 sameAs 1969132378 @default.
• W1969132378 citedByCount "66" @default.
• W1969132378 countsByYear W19691323782012 @default.
• W1969132378 countsByYear W19691323782013 @default.
• W1969132378 countsByYear W19691323782014 @default.
• W1969132378 countsByYear W19691323782015 @default.
• W1969132378 countsByYear W19691323782016 @default.
• W1969132378 countsByYear W19691323782017 @default.
• W1969132378 countsByYear W19691323782018 @default.
• W1969132378 countsByYear W19691323782019 @default.
• W1969132378 countsByYear W19691323782020 @default.
• W1969132378 countsByYear W19691323782021 @default.
• W1969132378 countsByYear W19691323782022 @default.
• W1969132378 countsByYear W19691323782023 @default.
• W1969132378 crossrefType "journal-article" @default.
• W1969132378 hasAuthorship W1969132378A5002722506 @default.
• W1969132378 hasAuthorship W1969132378A5029592340 @default.
• W1969132378 hasAuthorship W1969132378A5044699527 @default.
• W1969132378 hasAuthorship W1969132378A5091820929 @default.
• W1969132378 hasBestOaLocation W19691323782 @default.
• W1969132378 hasConcept C104317684 @default.
• W1969132378 hasConcept C176944494 @default.
• W1969132378 hasConcept C194232998 @default.
• W1969132378 hasConcept C199360897 @default.
• W1969132378 hasConcept C24586158 @default.
• W1969132378 hasConcept C2776023528 @default.
• W1969132378 hasConcept C2778220771 @default.
• W1969132378 hasConcept C41008148 @default.
• W1969132378 hasConcept C501734568 @default.
• W1969132378 hasConcept C54355233 @default.
• W1969132378 hasConcept C552990157 @default.
• W1969132378 hasConcept C64872895 @default.
• W1969132378 hasConcept C86803240 @default.
• W1969132378 hasConceptScore W1969132378C104317684 @default.
• W1969132378 hasConceptScore W1969132378C176944494 @default.
• W1969132378 hasConceptScore W1969132378C194232998 @default.
• W1969132378 hasConceptScore W1969132378C199360897 @default.
• W1969132378 hasConceptScore W1969132378C24586158 @default.
• W1969132378 hasConceptScore W1969132378C2776023528 @default.
• W1969132378 hasConceptScore W1969132378C2778220771 @default.
• W1969132378 hasConceptScore W1969132378C41008148 @default.
• W1969132378 hasConceptScore W1969132378C501734568 @default.
• W1969132378 hasConceptScore W1969132378C54355233 @default.
• W1969132378 hasConceptScore W1969132378C552990157 @default.
• W1969132378 hasConceptScore W1969132378C64872895 @default.
• W1969132378 hasConceptScore W1969132378C86803240 @default.
• W1969132378 hasIssue "10" @default.

• next