Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969132696> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1969132696 endingPage "338" @default.
- W1969132696 startingPage "335" @default.
- W1969132696 abstract "Cough is an important defensive reflex of the upper airway and is also a very common symptom of respiratory disease. Cough after an upper respiratory virus infection is transient, and persistent caugh is associated with a whole range of conditions such as asthma, rhino-sinusitis, gastro-oesophageal reflux. Treatment directed at these conditions may improve the associated cough. There is often a need, however, to control cough itself, whatever the cause. The most effective drugs in this class are the opioids, such as morphine, codeine or pholcodeine, but at effective doses they have side-effects such as drowsiness, nausea, constipation and physical dependence. Investigations into the cough reflex and into the potential mechanisms of sensitised cough reflex have uncovered several potential targets for novel drugs. New opioids such as k- and d-receptor agonists apart from m-agonists have been developed, in addition to non-opioid, nociceptin. Neurokinin receptor antagonists, bradykinin receptor antagonists, vanilloid receptor VR-1 antagonists may be beneficial by blocking effects of tachykinins, and sensory nerve activation. Local anaesthetics, blockers of sodium-dependent channels, and maxi-K CA2+-dependent channel activators of afferent nerves are inhibitors of the cough reflex. Some of these novel agents may act centrally or peripherally or at both sites as antitussives. Large scale trials of these novel compounds have not been tried in cough in man, but there is a serious need for more effective antitussives devoid of side-effects." @default.
- W1969132696 created "2016-06-24" @default.
- W1969132696 creator A5015755650 @default.
- W1969132696 creator A5054513704 @default.
- W1969132696 date "2002-05-01" @default.
- W1969132696 modified "2023-09-27" @default.
- W1969132696 title "Therapy for Cough: Active Agents" @default.
- W1969132696 cites W1973345298 @default.
- W1969132696 cites W2018137189 @default.
- W1969132696 cites W2027027734 @default.
- W1969132696 cites W2043257375 @default.
- W1969132696 cites W2055270402 @default.
- W1969132696 cites W2055467772 @default.
- W1969132696 cites W2058891531 @default.
- W1969132696 cites W2067436071 @default.
- W1969132696 cites W2080108502 @default.
- W1969132696 cites W2094755419 @default.
- W1969132696 cites W2097356981 @default.
- W1969132696 cites W2105788665 @default.
- W1969132696 cites W2165608049 @default.
- W1969132696 cites W2409961564 @default.
- W1969132696 cites W2550487184 @default.
- W1969132696 doi "https://doi.org/10.1006/pupt.2002.0342" @default.
- W1969132696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12099788" @default.
- W1969132696 hasPublicationYear "2002" @default.
- W1969132696 type Work @default.
- W1969132696 sameAs 1969132696 @default.
- W1969132696 citedByCount "37" @default.
- W1969132696 countsByYear W19691326962013 @default.
- W1969132696 countsByYear W19691326962014 @default.
- W1969132696 countsByYear W19691326962016 @default.
- W1969132696 countsByYear W19691326962021 @default.
- W1969132696 crossrefType "journal-article" @default.
- W1969132696 hasAuthorship W1969132696A5015755650 @default.
- W1969132696 hasAuthorship W1969132696A5054513704 @default.
- W1969132696 hasConcept C105922876 @default.
- W1969132696 hasConcept C125439840 @default.
- W1969132696 hasConcept C126322002 @default.
- W1969132696 hasConcept C170493617 @default.
- W1969132696 hasConcept C2777389121 @default.
- W1969132696 hasConcept C2777866328 @default.
- W1969132696 hasConcept C2780769369 @default.
- W1969132696 hasConcept C2781063702 @default.
- W1969132696 hasConcept C40956017 @default.
- W1969132696 hasConcept C42219234 @default.
- W1969132696 hasConcept C71924100 @default.
- W1969132696 hasConcept C83974742 @default.
- W1969132696 hasConcept C88016717 @default.
- W1969132696 hasConcept C98274493 @default.
- W1969132696 hasConceptScore W1969132696C105922876 @default.
- W1969132696 hasConceptScore W1969132696C125439840 @default.
- W1969132696 hasConceptScore W1969132696C126322002 @default.
- W1969132696 hasConceptScore W1969132696C170493617 @default.
- W1969132696 hasConceptScore W1969132696C2777389121 @default.
- W1969132696 hasConceptScore W1969132696C2777866328 @default.
- W1969132696 hasConceptScore W1969132696C2780769369 @default.
- W1969132696 hasConceptScore W1969132696C2781063702 @default.
- W1969132696 hasConceptScore W1969132696C40956017 @default.
- W1969132696 hasConceptScore W1969132696C42219234 @default.
- W1969132696 hasConceptScore W1969132696C71924100 @default.
- W1969132696 hasConceptScore W1969132696C83974742 @default.
- W1969132696 hasConceptScore W1969132696C88016717 @default.
- W1969132696 hasConceptScore W1969132696C98274493 @default.
- W1969132696 hasIssue "3" @default.
- W1969132696 hasLocation W19691326961 @default.
- W1969132696 hasLocation W19691326962 @default.
- W1969132696 hasOpenAccess W1969132696 @default.
- W1969132696 hasPrimaryLocation W19691326961 @default.
- W1969132696 hasRelatedWork W1950956993 @default.
- W1969132696 hasRelatedWork W1972844152 @default.
- W1969132696 hasRelatedWork W2006375516 @default.
- W1969132696 hasRelatedWork W2013286654 @default.
- W1969132696 hasRelatedWork W2093450161 @default.
- W1969132696 hasRelatedWork W2138295551 @default.
- W1969132696 hasRelatedWork W2401251560 @default.
- W1969132696 hasRelatedWork W2902638841 @default.
- W1969132696 hasRelatedWork W3012433284 @default.
- W1969132696 hasRelatedWork W4245739958 @default.
- W1969132696 hasVolume "15" @default.
- W1969132696 isParatext "false" @default.
- W1969132696 isRetracted "false" @default.
- W1969132696 magId "1969132696" @default.
- W1969132696 workType "article" @default.