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- W1969132849 abstract "1. Tritium labelled oestradiol-3 beta-D-glucuronide (E2-3G) was synthesised by sodium borohydride reduction of labelled oestrone-glucuronide (E1-G) and injected intravenously into anaesthetised rats. Bile and urine were collected to assess the routes and rate of excretion of E2-3G. Bile and urine samples were analysed by reverse phase HPLC to determine the metabolites of E2-3G. 2. When E2-3G was given at 11 and 22 mumol/kg, 83 and 85% respectively was excreted in bile within 3 hr and 1 and 3% in urine. 3. The major metabolite was E1-G which accounted for 89 and 92% respectively of the injected E2-3G which was recovered in bile. 4. It is concluded that bile is the major route of excretion of E2-3G in rats and that it is converted mainly to E1-G before excretion." @default.
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- W1969132849 date "1988-01-01" @default.
- W1969132849 modified "2023-09-25" @default.
- W1969132849 title "The metabolism and excretion of oestradiol-3β-d-glucuronide in rats" @default.
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- W1969132849 doi "https://doi.org/10.1016/0305-0491(88)90043-0" @default.
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