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- W1969133363 abstract "Exposure of cells to mild temperatures (40 °C) induces thermotolerance, which renders cells resistant to subsequent toxic insults. Thermotolerance is usually associated with accumulation of heat shock proteins. This study determines whether mild thermotolerance (40 °C, 3 h) can induce other defense proteins (e.g. antioxidants, anti-apoptosis proteins), and protect HeLa cells against apoptosis triggered by H2O2. Protein expression and enzymatic activity of MnSOD and catalase were increased in thermotolerant cells, as well as intracellular glutathione levels and γ-glutamylcysteine synthetase expression. Furthermore, levels of reactive oxygen species (ROS) were increased in thermotolerant cells, which caused mitochondrial membrane hyperpolarisation. Mild thermotolerance inhibited activation of the mitochondrial cascade of apoptosis by H2O2. This entailed inhibition of mitochondrial Bax translocation, mitochondrial membrane depolarisation, cytochrome c release, activation of caspases-9/-3 and chromatin condensation. Thermotolerance inhibited H2O2-induced caspase-independent apoptosis involving apoptosis-inducing factor, and activation of p53 and increased expression of its target protein PUMA. Thermotolerance induced at mild physiological temperatures protects cells against both caspase-dependent and caspase-independent apoptosis triggered by oxidative stress." @default.
- W1969133363 created "2016-06-24" @default.
- W1969133363 creator A5012924950 @default.
- W1969133363 creator A5076224086 @default.
- W1969133363 date "2010-03-01" @default.
- W1969133363 modified "2023-10-18" @default.
- W1969133363 title "Mild thermotolerance induced at 40°C increases antioxidants and protects HeLa cells against mitochondrial apoptosis induced by hydrogen peroxide: Role of p53" @default.
- W1969133363 cites W1683598352 @default.
- W1969133363 cites W1782545213 @default.
- W1969133363 cites W1963510913 @default.
- W1969133363 cites W1965284866 @default.
- W1969133363 cites W1966175867 @default.
- W1969133363 cites W1967715674 @default.
- W1969133363 cites W1969445527 @default.
- W1969133363 cites W1969789360 @default.
- W1969133363 cites W1975980695 @default.
- W1969133363 cites W1976065095 @default.
- W1969133363 cites W1977020389 @default.
- W1969133363 cites W1979013757 @default.
- W1969133363 cites W1981803037 @default.
- W1969133363 cites W1983386156 @default.
- W1969133363 cites W1990752413 @default.
- W1969133363 cites W1992667313 @default.
- W1969133363 cites W1993124877 @default.
- W1969133363 cites W1994318934 @default.
- W1969133363 cites W2000907682 @default.
- W1969133363 cites W2005627263 @default.
- W1969133363 cites W2006610864 @default.
- W1969133363 cites W2012461405 @default.
- W1969133363 cites W2013751209 @default.
- W1969133363 cites W2015657386 @default.
- W1969133363 cites W2019791345 @default.
- W1969133363 cites W2021358858 @default.
- W1969133363 cites W2023746083 @default.
- W1969133363 cites W2025179363 @default.
- W1969133363 cites W2028068328 @default.
- W1969133363 cites W2032603938 @default.
- W1969133363 cites W2034915619 @default.
- W1969133363 cites W2039191003 @default.
- W1969133363 cites W2042129455 @default.
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- W1969133363 cites W2065861852 @default.
- W1969133363 cites W2080378774 @default.
- W1969133363 cites W2084121419 @default.
- W1969133363 cites W2085042044 @default.
- W1969133363 cites W2087147392 @default.
- W1969133363 cites W2087790613 @default.
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- W1969133363 cites W2162748739 @default.
- W1969133363 cites W2164051171 @default.
- W1969133363 cites W2172249877 @default.
- W1969133363 cites W2210469066 @default.
- W1969133363 cites W2403490611 @default.
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- W1969133363 doi "https://doi.org/10.1016/j.abb.2009.12.014" @default.
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