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- W1969133783 abstract "The majority of cardiac anaesthetists in the UK use pancuronium for fast-track cardiac surgery. We compared the duration of action of pancuronium and rocuronium in patients undergoing fast-track hypothermic cardiopulmonary bypass and cardiac surgery. We determined whether patients would have had residual neuromuscular blockade at extubation. Twenty patients were randomly allocated to receive either pancuronium 0.1 mg x kg(-1) or rocuronium 1 mg x kg(-1). Neuromuscular function was assessed by acceleromyography; spontaneous recovery was evaluated by the train-of-four ratio measured at the adductor pollicis longus muscle. Median times to recover train-of-four ratio of 0.9 were 3 h 38 min for rocuronium and 7 h 52 min for pancuronium. The median difference in recovery times was 4 h 15 min (95% CI 2 h 30 min to 6 h 20 min; p = 0.0003 by Mann-Whitney test). None of the patients in the rocuronium group and seven of 10 patients in the pancuronium group had their extubations delayed because of residual neuromuscular blockade. Unless fast-track patients have neuromuscular function assessed before extubation, pancuronium should not be used." @default.
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- W1969133783 date "2003-02-21" @default.
- W1969133783 modified "2023-09-26" @default.
- W1969133783 title "Prospective randomised double-blind comparative study of rocuronium and pancuronium in adult patients scheduled for elective ‘fast-track’ cardiac surgery involving hypothermic cardiopulmonary bypass" @default.
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- W1969133783 doi "https://doi.org/10.1046/j.1365-2044.2003.30362.x" @default.
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