FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969134022> ?p ?o ?g. }

• W1969134022 endingPage "399" @default.
• W1969134022 startingPage "399" @default.
• W1969134022 abstract "In PC12 phaeochromocytoma cells, protein synthesis is activated by epidermal and nerve growth factors (EGF and NGF). EGF and NGF also regulate a number of components of the translational machinery in these cells. Here we show that the ability of EGF and NGF to induce the phosphorylation of the 70 kDa ribosomal protein, S6 kinase, and the eukaryotic initiation factor (eIF), 4E-binding protein 1, is dependent upon the presence of amino acids (but not glucose) in the medium. This resembles the regulation of these proteins by insulin, which also requires amino acids. Glucose, but not amino acids, is required for the activation of eIF2B by EGF and NGF. In contrast, EGF and NGF can still activate protein synthesis in the absence of nutrients, suggesting that other regulatory events are important in this. In nutrient-deprived cells, an increase in the phosphorylation of eIF4E, and the assembly of the eIF4F complex by EGF and NGF, coincided with the activation of protein synthesis. In serum-starved cells, activation of protein synthesis, phosphorylation of eIF4E, and formation of the eIF4F complex, were blocked by inhibition of MEK, a component of the extracellular regulated kinase (ERK) signalling pathway. Thus the ERK pathway plays a key role in the regulation of protein synthesis in PC12 cells." @default.
• W1969134022 created "2016-06-24" @default.
• W1969134022 creator A5030513468 @default.
• W1969134022 creator A5079590860 @default.
• W1969134022 date "2000-04-15" @default.
• W1969134022 modified "2023-10-16" @default.
• W1969134022 title "Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells" @default.
• W1969134022 cites W1531537331 @default.
• W1969134022 cites W1559266759 @default.
• W1969134022 cites W1597661683 @default.
• W1969134022 cites W1607579928 @default.
• W1969134022 cites W1689754237 @default.
• W1969134022 cites W1797700808 @default.
• W1969134022 cites W193359792 @default.
• W1969134022 cites W1966059275 @default.
• W1969134022 cites W1971915141 @default.
• W1969134022 cites W1979770710 @default.
• W1969134022 cites W1981001162 @default.
• W1969134022 cites W1987105275 @default.
• W1969134022 cites W1993836723 @default.
• W1969134022 cites W2001250888 @default.
• W1969134022 cites W2008239768 @default.
• W1969134022 cites W2009231286 @default.
• W1969134022 cites W2011596197 @default.
• W1969134022 cites W2016225291 @default.
• W1969134022 cites W2021669986 @default.
• W1969134022 cites W2028742041 @default.
• W1969134022 cites W2031599457 @default.
• W1969134022 cites W2032666422 @default.
• W1969134022 cites W2035016947 @default.
• W1969134022 cites W2047182549 @default.
• W1969134022 cites W2048006212 @default.
• W1969134022 cites W2051855988 @default.
• W1969134022 cites W2057327606 @default.
• W1969134022 cites W2058138221 @default.
• W1969134022 cites W2062801148 @default.
• W1969134022 cites W2066351162 @default.
• W1969134022 cites W2069207100 @default.
• W1969134022 cites W2069652470 @default.
• W1969134022 cites W2069826620 @default.
• W1969134022 cites W2086262311 @default.
• W1969134022 cites W2091805564 @default.
• W1969134022 cites W2097731453 @default.
• W1969134022 cites W2099136664 @default.
• W1969134022 cites W2114492564 @default.
• W1969134022 cites W2119194577 @default.
• W1969134022 cites W2119537218 @default.
• W1969134022 cites W2127354194 @default.
• W1969134022 cites W2131355261 @default.
• W1969134022 cites W2156730796 @default.
• W1969134022 cites W2157311365 @default.
• W1969134022 cites W2165604272 @default.
• W1969134022 cites W2170598671 @default.
• W1969134022 cites W2171830717 @default.
• W1969134022 cites W2263618575 @default.
• W1969134022 doi "https://doi.org/10.1042/0264-6021:3470399" @default.
• W1969134022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1220972" @default.
• W1969134022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10749669" @default.
• W1969134022 hasPublicationYear "2000" @default.
• W1969134022 type Work @default.
• W1969134022 sameAs 1969134022 @default.
• W1969134022 citedByCount "22" @default.
• W1969134022 countsByYear W19691340222013 @default.
• W1969134022 countsByYear W19691340222015 @default.
• W1969134022 crossrefType "journal-article" @default.
• W1969134022 hasAuthorship W1969134022A5030513468 @default.
• W1969134022 hasAuthorship W1969134022A5079590860 @default.
• W1969134022 hasBestOaLocation W19691340222 @default.
• W1969134022 hasConcept C104202773 @default.
• W1969134022 hasConcept C104317684 @default.
• W1969134022 hasConcept C105580179 @default.
• W1969134022 hasConcept C11960822 @default.
• W1969134022 hasConcept C149364088 @default.
• W1969134022 hasConcept C161295673 @default.
• W1969134022 hasConcept C170493617 @default.
• W1969134022 hasConcept C184235292 @default.
• W1969134022 hasConcept C2775960820 @default.
• W1969134022 hasConcept C2776362946 @default.
• W1969134022 hasConcept C2778423431 @default.
• W1969134022 hasConcept C2780044377 @default.
• W1969134022 hasConcept C2780926556 @default.
• W1969134022 hasConcept C3675279 @default.
• W1969134022 hasConcept C515207424 @default.
• W1969134022 hasConcept C55493867 @default.
• W1969134022 hasConcept C57074206 @default.
• W1969134022 hasConcept C62478195 @default.
• W1969134022 hasConcept C75217442 @default.
• W1969134022 hasConcept C86803240 @default.
• W1969134022 hasConcept C87325107 @default.
• W1969134022 hasConcept C95444343 @default.
• W1969134022 hasConcept C97029542 @default.
• W1969134022 hasConcept C97154109 @default.
• W1969134022 hasConceptScore W1969134022C104202773 @default.
• W1969134022 hasConceptScore W1969134022C104317684 @default.
• W1969134022 hasConceptScore W1969134022C105580179 @default.
• W1969134022 hasConceptScore W1969134022C11960822 @default.
• W1969134022 hasConceptScore W1969134022C149364088 @default.
• W1969134022 hasConceptScore W1969134022C161295673 @default.

• next