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- W1969134299 abstract "Witkin (1958, 1961) described an effect of acriflavine, caffeine and certain DNA combining basic dyes in increasing the magnitude of mutation frequency response to ultraviolet light in Escherichiacoli. In the study described here, we compared the effect of these agents on RNA, DNA and protein synthesis, survival and mutation induction with UV-exposed bacteria. The results establish that the agents exert some action on UV-exposed cells which results in increased mutation frequency response and lethality, as well as blockage of RNA, DNA and protein synthesis. The effects of acriflavine on macromolecular synthesis, mutation induction and lethality is described in this report. A subsequent report will describe identical effects of caffeine and the DNA combining dyes on UV-exposed bacteria." @default.
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- W1969134299 date "1964-02-01" @default.
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- W1969134299 title "Acriflavine modification of nucleic acid formation, mutation induction and survival in ultraviolet light exposed bacteria" @default.
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- W1969134299 doi "https://doi.org/10.1016/0006-291x(64)90105-6" @default.
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